Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.3561 | 1 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.3516 | 0.9872 | 0.9872 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.3516 | 0.9872 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.3561 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.3516 | 0.9872 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.2148 | 0.5995 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.3516 | 0.9872 | 0.9852 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0506 | 0.1343 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0506 | 0.1343 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1875 | 0.522 | 0.5216 |
Plasmodium vivax | hypothetical protein, conserved | 0.0506 | 0.1343 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0506 | 0.1343 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.3561 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidase | 0.0506 | 0.1343 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1343 | 0.1336 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0506 | 0.1343 | 0.1336 |
Onchocerca volvulus | 0.0035 | 0.0009 | 0.0009 | |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0506 | 0.1343 | 0.1343 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.3516 | 0.9872 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0506 | 0.1343 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.3561 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0506 | 0.1343 | 0.1336 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0506 | 0.1343 | 0.5 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0506 | 0.1343 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0506 | 0.1343 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0506 | 0.1343 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0506 | 0.1343 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.3561 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0506 | 0.1343 | 0.1336 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0506 | 0.1343 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1343 | 0.1336 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0506 | 0.1343 | 0.1336 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0506 | 0.1343 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0506 | 0.1343 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.3516 | 0.9872 | 0.9852 |
Plasmodium falciparum | peptidase, putative | 0.0506 | 0.1343 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0506 | 0.1343 | 0.5 |
Brugia malayi | hypothetical protein | 0.1641 | 0.456 | 0.4555 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0506 | 0.1343 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.3516 | 0.9872 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0506 | 0.1343 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.1641 | 0.456 | 0.4555 |
Brugia malayi | prolyl oligopeptidase family protein | 0.3516 | 0.9872 | 0.9872 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0506 | 0.1343 | 0.1336 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.3516 | 0.9872 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0506 | 0.1343 | 0.1336 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0506 | 0.1343 | 0.1336 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | 7964782 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 7964782 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.