Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | sema domain-containing protein | 0.0049 | 0.1165 | 0.2348 |
Echinococcus multilocularis | plexin a4 | 0.0139 | 0.4961 | 0.4961 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1165 | 0.1165 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.198 | 0.3991 |
Schistosoma mansoni | plexin | 0.0118 | 0.4053 | 0.4053 |
Echinococcus multilocularis | semaphorin 5B | 0.0049 | 0.1165 | 0.1165 |
Onchocerca volvulus | 0.0118 | 0.4053 | 1 | |
Schistosoma mansoni | semaphorin 5-related | 0.0049 | 0.1165 | 0.1165 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1165 | 0.2348 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1165 | 0.2348 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1165 | 0.2348 |
Echinococcus granulosus | semaphorin 5B | 0.0049 | 0.1165 | 0.1165 |
Echinococcus granulosus | plexin a4 | 0.0139 | 0.4961 | 0.4961 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1165 | 0.2348 |
Brugia malayi | Sema domain containing protein | 0.0049 | 0.1165 | 0.2348 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0259 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0027 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0049 | 0.1165 | 0.2348 |
Brugia malayi | Plexin repeat family protein | 0.0118 | 0.4053 | 0.8169 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | hypothetical protein | 0.0049 | 0.1165 | 0.1165 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1165 | 0.1165 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0027 | 0.0243 | 0.0243 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0259 | 1 | 1 |
Brugia malayi | Sema domain containing protein | 0.0049 | 0.1165 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1165 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1165 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0259 | 0.9996 | 0.9996 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1165 | 0.2348 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1165 | 0.2348 |
Entamoeba histolytica | protein kinase, putative | 0.0259 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0259 | 1 | 1 |
Brugia malayi | plexin A | 0.0139 | 0.4961 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0259 | 0.9996 | 0.9996 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.4053 | 0.8169 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | plexin A | 0.0139 | 0.4961 | 1 |
Schistosoma mansoni | plexin | 0.0069 | 0.198 | 0.198 |
Echinococcus granulosus | semaphorin 1A | 0.0049 | 0.1165 | 0.1165 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.198 | 0.198 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (functional) | = 146 % | Antitumor activity against mouse S180 cells xenografted ICR mouse at 50 mg/kg, ip relative to control | ChEMBL. | 3437287 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.