Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proliferating cell nuclear antigen | 0.00433242 | 1 | 1 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.00433242 | 1 | 1 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Loa Loa (eye worm) | proliferating cell nuclear antigen | 0.00433242 | 1 | 1 |
Trypanosoma cruzi | proliferative cell nuclear antigen (PCNA), putative | 0.00433242 | 1 | 0.5 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.00433242 | 1 | 0.5 |
Toxoplasma gondii | proliferating cell nuclear antigen PCNA1 | 0.00433242 | 1 | 0.5 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.00258047 | 0 | 0.5 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Brugia malayi | proliferating cell nuclear antigen (PCNA) | 0.00433242 | 1 | 1 |
Plasmodium vivax | proliferating cell nuclear antigen, putative | 0.00433242 | 1 | 0.5 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Echinococcus granulosus | proliferating cell nuclear antigen | 0.00433242 | 1 | 1 |
Trypanosoma cruzi | proliferative cell nuclear antigen (PCNA), putative | 0.00433242 | 1 | 0.5 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Leishmania major | proliferative cell nuclear antigen (PCNA), putative | 0.00433242 | 1 | 0.5 |
Plasmodium falciparum | proliferating cell nuclear antigen 1 | 0.00433242 | 1 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.00258047 | 0 | 0.5 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Entamoeba histolytica | proliferating cell nuclear antigen, putative | 0.00433242 | 1 | 0.5 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Echinococcus multilocularis | proliferating cell nuclear antigen | 0.00433242 | 1 | 1 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Giardia lamblia | PcnA | 0.00433242 | 1 | 0.5 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 | |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.00433242 | 1 | 0.5 |
Trypanosoma brucei | proliferative cell nuclear antigen (PCNA), putative | 0.00433242 | 1 | 0.5 |
Onchocerca volvulus | 0.00258047 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of Cdc25 | ChEMBL. | 12662092 | |
Activity (binding) | Inhibition of Cdc2/cyclin B | ChEMBL. | 12662092 | |
Activity (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml | ChEMBL. | 12662092 | |
IC50 (functional) | = 13 ug ml-1 | Antimalarial activity as Plasmodium falciparum DNA by PicoGreen microfluorimetry | ChEMBL. | 12662092 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 12662092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.