Detailed view for LOAG_10202

Basic information

TDR Targets ID: 943676
Loa Loa (eye worm), proliferating cell nuclear antigen
Source Database / ID:  KEGG  

pI: 4.3617 | Length (AA): 262 | MW (Da): 28974 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00705   Proliferating cell nuclear antigen, N-terminal domain
PF02747   Proliferating cell nuclear antigen, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003677   DNA binding  
GO:0030337   DNA polymerase processivity factor activity  
GO:0006275   regulation of DNA replication  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 255 5tup (A) 1 254 51.00 0 1 1.70488 -1.3
1 254 4hk1 (A) 1 254 53.00 0 1 1.63207 -0.91
1 255 2zvv (A) 1 255 49.00 0 1 1.68588 -1.31
2 262 3k4x (A) 2 278 39.00 0 1 1.53438 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127352)

Species Accession Gene Product
Arabidopsis thaliana AT1G07370   proliferating cellular nuclear antigen 1
Arabidopsis thaliana AT2G29570   proliferating cell nuclear antigen 2
Babesia bovis BBOV_IV002070   proliferating cell nuclear antigen 1
Brugia malayi Bm1_35280   proliferating cell nuclear antigen (PCNA)
Candida albicans CaO19.4616   PCNA-like orf
Candida albicans CaO19.12086   PCNA-like orf
Caenorhabditis elegans CELE_W03D2.4   Protein PCN-1
Cryptosporidium hominis Chro.80254   proliferating cell nuclear antigen (PCNA) (cyclin)
Cryptosporidium parvum cgd8_2150   proliferating cell nuclear antigen PCNA
Dictyostelium discoideum DDB_G0287607   proliferating cell nuclear antigen
Drosophila melanogaster Dmel_CG10262   CG10262 gene product from transcript CG10262-RA
Drosophila melanogaster Dmel_CG9193   Proliferating cell nuclear antigen
Echinococcus granulosus EgrG_000183500   proliferating cell nuclear antigen
Entamoeba histolytica EHI_128450   proliferating cell nuclear antigen, putative
Echinococcus multilocularis EmuJ_000183500   proliferating cell nuclear antigen
Giardia lamblia GL50803_6564   PcnA
Homo sapiens ENSG00000132646   proliferating cell nuclear antigen
Leishmania braziliensis LbrM.15.1440   proliferative cell nuclear antigen (PCNA), putative
Leishmania donovani LdBPK_151500.1   proliferative cell nuclear antigen (PCNA), putative
Leishmania infantum LinJ.15.1500   proliferative cell nuclear antigen (PCNA), putative
Leishmania major LmjF.15.1450   proliferative cell nuclear antigen (PCNA), putative
Leishmania mexicana LmxM.15.1450   proliferative cell nuclear antigen (PCNA), putative
Loa Loa (eye worm) LOAG_10202   proliferating cell nuclear antigen
Mus musculus ENSMUSG00000027342   proliferating cell nuclear antigen
Neospora caninum NCLIV_065280   Proliferating cell nuclear antigen, related
Oryza sativa 4331062   Os02g0805200
Plasmodium berghei PBANKA_1137900   proliferating cell nuclear antigen 1, putative
Plasmodium falciparum PF3D7_1361900   proliferating cell nuclear antigen 1
Plasmodium knowlesi PKNH_1109400   proliferating cell nuclear antigen 1, putative
Plasmodium vivax PVX_115055   proliferating cell nuclear antigen, putative
Plasmodium yoelii PY01758   proliferating cell nuclear antigen
Saccharomyces cerevisiae YBR088C   proliferating cell nuclear antigen
Schistosoma japonicum Sjp_0075590   ko:K04802 proliferating cell nuclear antigen, putative
Schistosoma mansoni Smp_046500.2   proliferating cell nuclear antigen
Schistosoma mansoni Smp_046500.1   proliferating cell nuclear antigen
Schmidtea mediterranea mk4.000845.01   Proliferating cell nuclear antigen
Schmidtea mediterranea mk4.003174.05   Proliferating cell nuclear antigen
Schmidtea mediterranea mk4.000077.09  
Schmidtea mediterranea mk4.003006.01  
Trypanosoma brucei gambiense Tbg972.9.2740   proliferative cell nuclear antigen (PCNA), putative
Trypanosoma brucei Tb927.9.5190   proliferative cell nuclear antigen (PCNA), putative
Trypanosoma congolense TcIL3000_9_1700   proliferative cell nuclear antigen (PCNA), putative
Trypanosoma cruzi TcCLB.507913.30   proliferative cell nuclear antigen (PCNA), putative
Trypanosoma cruzi TcCLB.508277.150   proliferative cell nuclear antigen (PCNA), putative
Toxoplasma gondii TGME49_247460   proliferating cell nuclear antigen PCNA1
Theileria parva TP03_0445   proliferating cell nuclear antigen, putative
Trichomonas vaginalis TVAG_291710   proliferating cell nuclear antigen, putative
Trichomonas vaginalis TVAG_092580   proliferating cell nuclear antigen, putative

Essentiality

LOAG_10202 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.3710 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.160.3710 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.3710 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.160.3710 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_W03D2.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_W03D2.4 Caenorhabditis elegans sterile wormbase
YBR088C Saccharomyces cerevisiae inviable yeastgenome
TGME49_247460 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens proliferating cell nuclear antigen Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.00433242 1 1
0.0038 1 0.5
0.0038 0.6792 0.6792
0.0031 1 0.5
0.0038 1 0.5
0.0097 1 1
0.0136 0.265 1
0.0072 1 1
0.0138 0.3623 0.3623
0.0093 0.2782 0.2782
0.0031 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_10202 (Loa Loa (eye worm)), proliferating cell nuclear antigen
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