Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | plexin a4 | 0.0138 | 0.5224 | 0.5189 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0049 | 0.1626 | 0.2348 |
Brugia malayi | Sema domain containing protein | 0.0049 | 0.1626 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1626 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0522 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0522 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1626 | 0.1564 |
Echinococcus granulosus | exocyst complex component 2 | 0.0021 | 0.0522 | 0.0453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0522 | 0.5 |
Schistosoma mansoni | plexin | 0.0068 | 0.2398 | 0.2343 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0522 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1626 | 0.2348 |
Echinococcus granulosus | plexin a4 | 0.0138 | 0.5224 | 0.5189 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0522 | 0.0522 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0522 | 0.0522 |
Brugia malayi | plexin A | 0.0138 | 0.5224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2398 | 0.3991 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2398 | 0.2343 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1626 | 0.2348 |
Loa Loa (eye worm) | plexin A | 0.0138 | 0.5224 | 1 |
Entamoeba histolytica | cell surface protease gp63, putative | 0.0021 | 0.0522 | 0.0522 |
Entamoeba histolytica | protein kinase, putative | 0.0256 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0021 | 0.0522 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0256 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0021 | 0.0522 | 0.5 |
Leishmania major | protein kinase, putative | 0.001 | 0.0073 | 0.5 |
Echinococcus granulosus | semaphorin 5B | 0.0049 | 0.1626 | 0.1564 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0256 | 1 | 1 |
Brugia malayi | Sema domain containing protein | 0.0049 | 0.1626 | 0.2348 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0049 | 0.1626 | 0.2348 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0522 | 0.0453 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0256 | 0.9996 | 0.9996 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1626 | 0.2348 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0522 | 0.0453 |
Plasmodium falciparum | protein kinase, putative | 0.001 | 0.0073 | 0.5 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0029 | 0.085 | 0.085 |
Echinococcus granulosus | transcription factor collier | 0.0021 | 0.0522 | 0.0453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0522 | 0.5 |
Echinococcus granulosus | semaphorin 1A | 0.0049 | 0.1626 | 0.1564 |
Onchocerca volvulus | 0.0116 | 0.4363 | 1 | |
Schistosoma mansoni | semaphorin 5-related | 0.0049 | 0.1626 | 0.1564 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0021 | 0.0522 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1626 | 0.1564 |
Entamoeba histolytica | protein kinase domain containing protein | 0.001 | 0.0073 | 0.0073 |
Brugia malayi | Plexin repeat family protein | 0.0116 | 0.4363 | 0.8169 |
Echinococcus multilocularis | hypothetical protein | 0.0049 | 0.1626 | 0.1564 |
Schistosoma mansoni | plexin | 0.0116 | 0.4363 | 0.4322 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.001 | 0.0073 | 0.5 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0021 | 0.0522 | 0.5 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.001 | 0.0073 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0522 | 0.5 |
Echinococcus multilocularis | exocyst complex component 2 | 0.0021 | 0.0522 | 0.0453 |
Entamoeba histolytica | protein kinase, putative | 0.0256 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0021 | 0.0522 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0029 | 0.085 | 0.085 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0256 | 0.9996 | 0.9996 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0522 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0522 | 0.0522 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.001 | 0.0073 | 0.5 |
Echinococcus multilocularis | transcription factor collier | 0.0021 | 0.0522 | 0.0453 |
Echinococcus multilocularis | semaphorin 5B | 0.0049 | 0.1626 | 0.1564 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1626 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1626 | 0.2348 |
Trypanosoma brucei | protein kinase, putative | 0.001 | 0.0073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.4363 | 0.8169 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0522 | 0.5 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.001 | 0.0073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1626 | 0.2348 |
Schistosoma mansoni | fibrocystin l | 0.0021 | 0.0522 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1626 | 0.2348 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of recombinant EphB4R by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 | |
IC50 (binding) | Inhibition of recombinant VEGFR2 by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 | |
IC50 (binding) | Inhibition of recombinant c-Src by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 | |
IC50 (binding) | Inhibition of recombinant PI4Kbeta by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 | |
IC50 (binding) | Inhibition of recombinant c-Abl by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 | |
IC50 (binding) | Inhibition of recombinant HCK by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 | |
IC50 (binding) | Inhibition of recombinant EGFR by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 | |
IC50 (binding) | = 100 uM | Inhibition of recombinant PI3Kalpha by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 |
IC50 (binding) | = 100 uM | Inhibition of recombinant PI3Kbeta by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 |
IC50 (binding) | = 100 uM | Inhibition of recombinant PI3Kdelta by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 |
IC50 (binding) | = 100 uM | Inhibition of recombinant PI3Kgamma by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 |
IC50 (binding) | = 100 uM | Inhibition of DNA-PK by radioactive phosphotransfer assay in presence of 10 uM ATP | ChEMBL. | 18849971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.