Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0118 | 0.0177 | 0.0744 |
Echinococcus multilocularis | patatin phospholipase domain containing protein | 0.0156 | 0.0273 | 0.1151 |
Loa Loa (eye worm) | amidase | 0.0118 | 0.0177 | 0.0744 |
Echinococcus granulosus | patatin phospholipase domain containing protein | 0.0156 | 0.0273 | 0.1151 |
Schistosoma mansoni | amidase | 0.0981 | 0.2373 | 1 |
Onchocerca volvulus | 0.0156 | 0.0273 | 1 | |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0819 | 0.1961 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0981 | 0.2373 | 1 |
Giardia lamblia | Protein phosphatase methylesterase-1 | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0118 | 0.0177 | 0.0177 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0118 | 0.0177 | 0.0901 |
Brugia malayi | Amidase family protein | 0.0118 | 0.0177 | 0.0744 |
Plasmodium falciparum | lysophospholipase, putative | 0.0819 | 0.1961 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0118 | 0.0177 | 0.0177 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0981 | 0.2373 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0981 | 0.2373 | 1 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Trypanosoma cruzi | amidase, putative | 0.0118 | 0.0177 | 0.0901 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0981 | 0.2373 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0819 | 0.1961 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0819 | 0.1961 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0981 | 0.2373 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0819 | 0.1961 | 1 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | amidase | 0.0118 | 0.0177 | 0.0744 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0118 | 0.0177 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0819 | 0.1961 | 0.1961 |
Brugia malayi | amidase | 0.0981 | 0.2373 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0819 | 0.1961 | 1 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0118 | 0.0177 | 0.0744 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0118 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0156 | 0.0273 | 0.0273 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0118 | 0.0177 | 0.0177 |
Giardia lamblia | ENC6 protein | 0.0049 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0118 | 0.0177 | 0.0847 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0144 | 0.0243 | 0.1023 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0819 | 0.1961 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0868 | 0.2085 | 0.2085 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0819 | 0.1961 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0819 | 0.1961 | 0.5 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0118 | 0.0177 | 0.0177 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0868 | 0.2085 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0118 | 0.0177 | 0.0901 |
Plasmodium vivax | PST-A protein | 0.0819 | 0.1961 | 1 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0118 | 0.0177 | 0.0744 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0118 | 0.0177 | 0.0744 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0118 | 0.0177 | 0.8064 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0144 | 0.0243 | 0.1023 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0819 | 0.1961 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Giardia lamblia | Hypothetical protein | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0118 | 0.0177 | 0.0177 |
Brugia malayi | putative amidase | 0.0118 | 0.0177 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0273 | 0.1151 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.3976 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0981 | 0.2373 | 1 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0049 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0118 | 0.0177 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0118 | 0.0177 | 0.0744 |
Treponema pallidum | hypothetical protein | 0.0135 | 0.0219 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0118 | 0.0177 | 0.0847 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0118 | 0.0177 | 0.0744 |
Leishmania major | monoglyceride lipase, putative | 0.0819 | 0.1961 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0819 | 0.1961 | 1 |
Giardia lamblia | Hypothetical protein | 0.0049 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0118 | 0.0177 | 0.0901 |
Brugia malayi | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative | 0.0156 | 0.0273 | 0.1151 |
Brugia malayi | Amidase family protein | 0.0118 | 0.0177 | 0.0744 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0819 | 0.1961 | 0.1961 |
Plasmodium falciparum | esterase, putative | 0.0819 | 0.1961 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0118 | 0.0177 | 0.0177 |
Toxoplasma gondii | chain a, pp2a-specific methylesterase apo form (pme), putative | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.