Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 0.6165 | 0.6165 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0256 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 0.6165 | 0.6165 |
Trypanosoma cruzi | GMP reductase | 0.0256 | 1 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0256 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 0.6165 | 0.6165 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0065 | 0 | 0.5 |
Onchocerca volvulus | 0.0182 | 0.6165 | 1 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0182 | 0.6165 | 0.6165 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0256 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 0.6165 | 0.6165 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0065 | 0 | 0.5 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0241 | 0.9205 | 1 |
Giardia lamblia | Histone deacetylase | 0.0065 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0256 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.6165 | 0.6165 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0256 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0256 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.6165 | 0.6165 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0241 | 0.9205 | 0.8869 |
Brugia malayi | GMP reductase | 0.0106 | 0.2171 | 0.2171 |
Entamoeba histolytica | histone deacetylase, putative | 0.0065 | 0 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0106 | 0.2171 | 0.2171 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0065 | 0 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0256 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0134 | 0.3638 | 0.0954 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.6165 | 0.6165 |
Loa Loa (eye worm) | GMP reductase | 0.0106 | 0.2171 | 0.2171 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0256 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 0.6165 | 0.6165 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 0.6165 | 0.6165 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0241 | 0.9205 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0065 | 0 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0256 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0106 | 0.2171 | 0.2171 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 0.6165 | 0.6165 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0256 | 1 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0256 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0256 | 1 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0256 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0256 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0065 | 0 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0.6165 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0256 | 1 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0256 | 1 | 1 |
Trypanosoma brucei | GMP reductase | 0.0256 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0065 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells by SPA | ChEMBL. | 18621528 | |
Ki (binding) | = 63 nM | Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPA | ChEMBL. | 18621528 |
Ki (binding) | = 133 nM | Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPA | ChEMBL. | 18621528 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.