Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.2961 | 0.2961 |
Schistosoma mansoni | amidase | 0.0123 | 0.2961 | 0.2961 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 0.4384 | 0.5 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0369 | 1 | 1 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.2961 | 0.2961 |
Brugia malayi | amidase | 0.0123 | 0.2961 | 0.6753 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.2961 | 0.2961 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.4384 | 1 |
Loa Loa (eye worm) | lipase | 0.0173 | 0.4384 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0293 | 0.7829 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.4384 | 0.4384 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.4384 | 1 |
Giardia lamblia | Thymus-specific serine protease precursor | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0293 | 0.7829 | 0.5 |
Toxoplasma gondii | serine carboxypeptidase s28 protein | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0369 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.2961 | 0.2961 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.4384 | 1 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.002 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.2961 | 0.2961 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.4384 | 0.4384 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.4384 | 0.5 |
Brugia malayi | Lipase family protein | 0.0173 | 0.4384 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.4384 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.2961 | 0.6753 |
Onchocerca volvulus | 0.0173 | 0.4384 | 1 | |
Giardia lamblia | Serine peptidase, putative | 0.002 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.4384 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Inhibition of human recombinant DAGL-alpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey COS7 cell membrane by scintillation counting | ChEMBL. | 18831576 |
IC50 (binding) | = 3.4 uM | Inhibition of FAAH-mediated [14C]anandamide hydrolysis in rat brain membrane | ChEMBL. | 18831576 |
Ki (binding) | = 1.7 uM | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting | ChEMBL. | 18831576 |
Ki (binding) | = 7.4 uM | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting | ChEMBL. | 18831576 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.