Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.6855 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 1 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0015 | 0 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0015 | 0 | 0.5 |
Brugia malayi | amidase | 0.0123 | 0.6855 | 0.6855 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.6855 | 0.6855 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0015 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.6855 | 0.6855 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0015 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0173 | 1 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.6855 | 0.6855 |
Mycobacterium ulcerans | amidase | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 1 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.6855 | 0.6855 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 1 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0173 | 1 | 0.5 | |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | amidase | 0.0123 | 0.6855 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.6855 | 0.6855 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0015 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.43 uM | Inhibition of human recombinant DAGL-alpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey COS7 cell membrane by scintillation counting | ChEMBL. | 18831576 |
IC50 (binding) | = 6.6 uM | Inhibition of FAAH-mediated [14C]anandamide hydrolysis in rat brain membrane | ChEMBL. | 18831576 |
Ki (binding) | = 8.6 uM | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting | ChEMBL. | 18831576 |
Ki (binding) | > 10 uM | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting | ChEMBL. | 18831576 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.