Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.57 uM | Antiinflammatory activity against po dosed monosodium urate crystal-induced C57BL/J6 mouse acute gouty arthritis model | ChEMBL. | 18835721 |
IC50 (functional) | = 91 uM | Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay | ChEMBL. | 18835721 |
Inhibition (functional) | = 2 % | Antiinflammatory activity against C57BL/J6 mouse acute gouty arthritis model assessed as suppression of monosodium urate crystal-induced neutrophil superoxide production at 2.5 mg/kg, po | ChEMBL. | 18835721 |
Inhibition (functional) | = 5 % | Antiinflammatory activity against C57BL/J6 mouse acute gouty arthritis model assessed as inhibition of monosodium urate crystal-induced neutrophil infiltration at 2.5 mg/kg, po | ChEMBL. | 18835721 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.