Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0117 | 0 | 0.5 |
Onchocerca volvulus | 0.018 | 1 | 0.5 | |
Schistosoma mansoni | amidase | 0.0117 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0165 | 0.7697 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0117 | 0 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0117 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.018 | 1 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.018 | 1 | 0.5 |
Onchocerca volvulus | 0.018 | 1 | 0.5 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0165 | 0.7697 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.018 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0165 | 0.7697 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0165 | 0.7697 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0117 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0117 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.