Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetyltransferase | 0.0148 | 0.3611 | 0.3611 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0512 | 0.0512 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.133 | 0.133 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0512 | 0.0512 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 1 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0148 | 0.3611 | 0.3611 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.0751 | 0.05 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.133 | 0.133 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0264 | 0.0264 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.133 | 0.133 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0382 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.133 | 0.133 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.0751 | 0.05 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0382 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.133 | 0.133 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0382 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0953 | 0.0953 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0144 | 0.3498 | 0.3498 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0382 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.0751 | 0.05 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0382 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0382 | 1 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.133 | 0.133 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.0751 | 0.0751 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0382 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0953 | 0.0953 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.133 | 0.133 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.133 | 0.133 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0512 | 0.0512 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0148 | 0.3611 | 0.3611 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.133 | 0.133 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0382 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0382 | 1 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0148 | 0.3611 | 0.3611 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0953 | 0.0953 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0953 | 0.0953 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0382 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.133 | 0.133 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0382 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.133 | 0.133 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0382 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0264 | 0.0264 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0382 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0382 | 1 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0382 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0382 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.133 | 0.133 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.133 | 0.133 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0382 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0382 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0382 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0651 | 0.0398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.