Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | DNA topoisomerase 1 | 0.02 | 0.7304 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.014 | 0.486 | 0.6654 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0267 | 1 | 1 |
Plasmodium vivax | topoisomerase I, putative | 0.02 | 0.7304 | 0.5 |
Brugia malayi | DNA topoisomerase I | 0.02 | 0.7304 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.015 | 0.527 | 0.7215 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.02 | 0.7304 | 1 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.015 | 0.527 | 0.4599 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.02 | 0.7304 | 1 |
Onchocerca volvulus | 0.0144 | 0.501 | 1 | |
Leishmania major | DNA topoisomerase IB, large subunit | 0.015 | 0.527 | 0.4599 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.501 | 0.6859 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.02 | 0.7304 | 0.5 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0125 | 0.4238 | 0.5802 |
Plasmodium falciparum | topoisomerase I | 0.02 | 0.7304 | 0.5 |
Schistosoma mansoni | DNA topoisomerase type I | 0.02 | 0.7304 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.4841 | 0.6628 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.015 | 0.527 | 0.4599 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.4219 | 0.5776 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.014 | 0.486 | 0.6654 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0267 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.015 | 0.527 | 0.7215 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0267 | 1 | 1 |
Onchocerca volvulus | 0.0139 | 0.4841 | 0.7864 | |
Schistosoma mansoni | protein kinase C mu | 0.014 | 0.486 | 0.6654 |
Brugia malayi | C1-like domain containing protein | 0.014 | 0.486 | 0.6654 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.4219 | 0.5776 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.25 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae after 48 hrs by macro tube dilution method | ChEMBL. | 19084292 |
MIC (functional) | = 100 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by macro tube dilution method | ChEMBL. | 19084292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.