Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | endoprotease bli-4 | 0.0439 | 0.399 | 0.399 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0694 | 0.0694 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0104 | 0.03 | 0.1032 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0104 | 0.03 | 0.1032 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0242 | 0.1818 | 0.1818 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.014 | 0.0694 | 0.0848 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0276 | 0.2195 | 0.2682 |
Onchocerca volvulus | CoRest homolog | 0.0175 | 0.1078 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0104 | 0.03 | 0.1032 |
Brugia malayi | SWIRM domain containing protein | 0.0151 | 0.0824 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0986 | 1 | 1 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0104 | 0.03 | 0.0751 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0104 | 0.03 | 0.1032 |
Echinococcus granulosus | Furin 1 | 0.0104 | 0.03 | 0.0366 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0977 | 0.2448 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.1078 | 0.1078 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0191 | 0.126 | 0.3158 |
Echinococcus multilocularis | Furin 1 | 0.0104 | 0.03 | 0.0366 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.082 | 0.8182 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.014 | 0.0694 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1054 | 0.1054 |
Echinococcus granulosus | furin | 0.0439 | 0.399 | 0.4877 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.399 | 0.399 |
Brugia malayi | endoprotease bli-4 precursor | 0.0439 | 0.399 | 0.399 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.082 | 0.8182 | 1 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0276 | 0.2195 | 0.2195 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0267 | 0.2095 | 1 |
Echinococcus multilocularis | 0.0354 | 0.3055 | 0.3734 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0165 | 0.0977 | 0.0977 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0104 | 0.03 | 0.03 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0267 | 0.2095 | 0.256 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.1024 | 0.1024 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0439 | 0.399 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0267 | 0.2095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0824 | 0.0824 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0276 | 0.2195 | 0.2682 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.017 | 0.1024 | 0.1024 |
Brugia malayi | proprotein convertase 2 | 0.0276 | 0.2195 | 0.2195 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0694 | 0.0694 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0093 | 0.0233 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.014 | 0.0694 | 0.1739 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0104 | 0.03 | 0.1032 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0242 | 0.1818 | 0.1818 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0163 | 0.0954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0977 | 0.0977 |
Brugia malayi | celfurPC protein | 0.0354 | 0.3055 | 0.3055 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0104 | 0.03 | 0.1032 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0267 | 0.2095 | 0.256 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 10 mm | Antibacterial activity against Escherichia coli ATTC 25922 after 3 to 4 days by serial plate dilution method | ChEMBL. | 20542604 |
IZ (functional) | = 10 mm | Antifungal activity against Candida albicans after 3 to 4 days by serial plate dilution method | ChEMBL. | 20542604 |
MIC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida albicans after 3 to 4 days by serial plate dilution method | ChEMBL. | 20542604 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Escherichia coli ATTC 25922 after 3 to 4 days by serial plate dilution method | ChEMBL. | 20542604 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.