Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosine kinase, non-receptor, 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.3299 | 0.6728 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1226 | 0.1226 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.4747 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.2921 | 0.2921 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.02 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0104 | 0.4747 | 0.4747 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0104 | 0.4747 | 0.4747 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.2921 | 0.5957 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.2921 | 0.2921 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0104 | 0.4708 | 0.4708 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1031 | 0.1031 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3243 | 0.3243 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.02 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.4747 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2056 | 0.2056 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0104 | 0.4747 | 0.4747 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0107 | 0.4904 | 0.4904 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.4747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3243 | 0.3243 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2056 | 0.2056 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.3299 | 0.3299 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2726 | 0.2726 |
Echinococcus multilocularis | transfer RNA-Thr | 0.02 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0104 | 0.4747 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0104 | 0.4747 | 0.4747 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.2921 | 0.2921 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1104 | 0.1104 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.4747 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0107 | 0.4904 | 1 |
Schistosoma mansoni | kinase | 0.0053 | 0.1944 | 0.3965 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0104 | 0.4747 | 0.5 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.02 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1104 | 0.1104 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0107 | 0.4904 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.9944 | 0.9944 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0078 | 0.3299 | 0.3299 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2056 | 0.2056 |
Brugia malayi | Transient-receptor-potential like protein | 0.004 | 0.1226 | 0.1226 |
Echinococcus multilocularis | protein KINase family member (kin 25) | 0.0078 | 0.3299 | 0.3299 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0104 | 0.4747 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0104 | 0.4747 | 0.968 |
Giardia lamblia | Kinase, PLK | 0.0104 | 0.4747 | 0.5 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.004 | 0.1226 | 0.1226 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.4747 | 1 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.004 | 0.1226 | 0.1226 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0104 | 0.4747 | 0.5 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0107 | 0.4904 | 0.4904 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0104 | 0.4747 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.4747 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1104 | 0.2252 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.2921 | 0.2921 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0104 | 0.4747 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.4904 | 0.4904 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0104 | 0.4708 | 0.4708 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2056 | 0.2056 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.4747 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.2921 | 0.5957 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.005 uM | Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) expressed in SF9 cells | ChEMBL. | 18993068 |
Ki (binding) | = 0.02 uM | Inhibition of flag-tagged ACK1 autophosphorylation expressed in human 293 cells | ChEMBL. | 18993068 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.