Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IL2-inducible T-cell kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Tyrosine-protein kinase BTK, putative | Get druggable targets OG5_129320 | All targets in OG5_129320 |
Schistosoma japonicum | ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative | Get druggable targets OG5_129320 | All targets in OG5_129320 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | Get druggable targets OG5_129320 | All targets in OG5_129320 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_129320 | All targets in OG5_129320 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | Get druggable targets OG5_129320 | All targets in OG5_129320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0007 | 0.0133 | 0.0135 |
Brugia malayi | Variant SH3 domain containing protein | 0.0006 | 0.008 | 0.0108 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0167 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0007 | 0.0133 | 0.0178 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0007 | 0.0133 | 0.0053 |
Schistosoma mansoni | adapter molecule crk | 0.0006 | 0.008 | 0.0082 |
Schistosoma mansoni | nck2/grb4 | 0.0006 | 0.008 | 0.0082 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0007 | 0.0133 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.008 | 0.0108 |
Brugia malayi | Protein kinase domain containing protein | 0.0126 | 0.7456 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0007 | 0.0133 | 0.0053 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0007 | 0.0133 | 0.0053 |
Brugia malayi | Fibroblast growth factor family protein | 0.0059 | 0.3348 | 0.449 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0006 | 0.008 | 0.0082 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0007 | 0.0133 | 0.0053 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0006 | 0.008 | 0.0108 |
Loa Loa (eye worm) | SRC-1 | 0.0007 | 0.0133 | 0.0178 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0007 | 0.0133 | 0.0053 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0007 | 0.0133 | 0.0053 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0007 | 0.0133 | 0.0053 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0006 | 0.008 | 0.0108 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0007 | 0.0133 | 0.0053 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0007 | 0.0133 | 0.0053 |
Brugia malayi | Fibroblast growth factor family protein | 0.0059 | 0.3348 | 0.449 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0007 | 0.0133 | 0.0053 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0006 | 0.008 | 0.0082 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0007 | 0.0133 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3348 | 0.449 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.7456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3348 | 0.449 |
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.9818 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0007 | 0.0133 | 0.0053 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0007 | 0.0133 | 0.0053 |
Brugia malayi | Variant SH3 domain containing protein | 0.0006 | 0.008 | 0.0108 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0007 | 0.0133 | 0.0135 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0007 | 0.0133 | 0.0178 |
Giardia lamblia | Hypothetical protein | 0.0059 | 0.3348 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0007 | 0.0133 | 0.0053 |
Schistosoma mansoni | tyrosine kinase | 0.0007 | 0.0133 | 0.0135 |
Echinococcus granulosus | c src tyrosine kinase | 0.0007 | 0.0133 | 0.0053 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0007 | 0.0133 | 0.0053 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0007 | 0.0133 | 0.0053 |
Schistosoma mansoni | tyrosine kinase | 0.0007 | 0.0133 | 0.0135 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0006 | 0.008 | 0.0082 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0007 | 0.0133 | 0.0053 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0006 | 0.008 | 0.0108 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0007 | 0.0133 | 0.0053 |
Schistosoma mansoni | tyrosine kinase | 0.0007 | 0.0133 | 0.0135 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.036 uM | Inhibition of ITK by DELPHIA assay | ChEMBL. | 18823779 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.