Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0157 | 0.2058 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0157 | 0.2058 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0157 | 0.2058 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0239 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0157 | 0.2058 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0239 | 1 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0239 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0157 | 0.2058 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0157 | 0.2058 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0157 | 0.2058 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0157 | 0.2058 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0239 | 1 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0136 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0157 | 0.2058 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.