Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0158 | 0.1186 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0874 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0093 | 0.0389 | 0.0389 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.1038 | 0.1229 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0748 | 0.8444 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.022 | 0.1944 | 0.1944 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0093 | 0.0389 | 0.0389 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0093 | 0.0389 | 0.0389 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0093 | 0.0389 | 0.0389 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0146 | 0.1038 | 0.1038 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0093 | 0.0389 | 0.0389 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0158 | 0.1186 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0093 | 0.0389 | 0.0389 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0093 | 0.0389 | 0.0389 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0093 | 0.0389 | 0.0389 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.1038 | 0.1229 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0158 | 0.1186 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0093 | 0.0389 | 0.0389 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0093 | 0.0389 | 0.0389 |
Chlamydia trachomatis | glutamine binding protein | 0.0158 | 0.1186 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0654 | 0.7297 | 0.7297 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0686 | 0.7686 | 0.7686 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0158 | 0.1186 | 0.5 |
Echinococcus multilocularis | geminin | 0.0146 | 0.1038 | 0.1038 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0686 | 0.7686 | 0.7686 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0654 | 0.7297 | 0.7297 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0062 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0158 | 0.1186 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 12 uM | Cytotoxicity against human KB cells after 72 hrs | ChEMBL. | 18503262 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18503262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.