Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0082 | 0.0635 | 0.0635 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.238 | 0.238 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0135 | 0.1945 | 0.1687 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0135 | 0.1945 | 0.1945 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0135 | 0.1945 | 0.1945 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0083 | 0.0655 | 0.0655 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.0844 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.238 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0082 | 0.0635 | 0.0635 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0078 | 0.0519 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0078 | 0.0519 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0082 | 0.0635 | 0.0635 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0178 | 0.3001 | 0.3001 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0082 | 0.0635 | 0.0635 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0082 | 0.0635 | 0.0635 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0191 | 0.3326 | 0.3326 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0383 | 0.0353 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0153 | 0.238 | 0.2137 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0082 | 0.0635 | 0.0635 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0082 | 0.0635 | 0.0635 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0082 | 0.0635 | 0.0635 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0083 | 0.0655 | 0.1668 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.238 | 0.238 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.046 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0082 | 0.0635 | 0.0635 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.046 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0083 | 0.0655 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0083 | 0.0655 | 0.0655 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0191 | 0.3326 | 0.3326 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0178 | 0.3001 | 0.3001 |
Schistosoma mansoni | glutamate receptor NMDA | 0.026 | 0.5042 | 0.4884 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0203 | 0.3636 | 0.3636 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0203 | 0.3636 | 0.3636 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0153 | 0.238 | 0.238 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0069 | 0.0309 | 0.0309 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0082 | 0.0635 | 0.0635 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.238 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.0844 | 0.0552 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 11.5 nM | Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells | ChEMBL. | 19326916 |
Ki (binding) | = 250 nM | Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells | ChEMBL. | 19326916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.