Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0167 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0364 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0167 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.0167 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.0167 | 0.023 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.0167 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0167 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0071 | 0.4244 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.0167 | 0.459 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0071 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0071 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0759 | 0.2691 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0071 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0759 | 0.2691 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0071 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.0167 | 0.459 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.0167 | 0.023 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0071 | 0.4244 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0071 | 0.0098 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0364 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.202 | 0.7253 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0071 | 0.4244 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0759 | 0.2691 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0759 | 0.2691 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0167 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0167 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0759 | 0.2691 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0759 | 0.2691 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0759 | 0.2691 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0759 | 0.2691 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.0167 | 0.459 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0071 | 0.4244 |
Brugia malayi | RNA binding protein | 0.0061 | 0.0167 | 0.023 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0364 | 0.0502 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1 uM | Growth inhibition of human DU145 cells after 96 hrs by trypan blue exclusion assay | ChEMBL. | 20188579 |
GI50 (functional) | = 10 uM | Growth inhibition of human K562 cells expressing p210Bcr/Abl after 96 hrs by trypan blue exclusion assay | ChEMBL. | 20188579 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.