Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | prolyl oligopeptidase family protein | 0.0168 | 0.2787 | 0.4458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0168 | 0.2787 | 0.4664 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0106 | 0.1308 | 0.1308 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.2993 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.2408 | 0.2408 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0168 | 0.2787 | 0.2787 |
Brugia malayi | amidase | 0.0106 | 0.1308 | 0.2092 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0206 | 0.3703 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0056 | 0.0115 | 0.0115 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0168 | 0.2787 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0056 | 0.0115 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0056 | 0.0115 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0056 | 0.0115 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1308 | 0.2189 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.5977 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0056 | 0.0115 | 0.0385 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0106 | 0.1308 | 0.1308 |
Schistosoma mansoni | amidase | 0.0106 | 0.1308 | 0.437 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0056 | 0.0115 | 0.0184 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0106 | 0.1308 | 0.437 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0168 | 0.2787 | 0.2787 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0056 | 0.0115 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0469 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.2408 | 0.8044 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0106 | 0.1308 | 0.1308 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.5977 | 0.9558 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.2993 | 0.2993 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0469 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0056 | 0.0115 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.5977 | 0.9558 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.5944 | 0.9945 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0469 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.6253 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.2993 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.2408 | 0.2408 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0168 | 0.2787 | 0.9312 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0056 | 0.0115 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0056 | 0.0115 | 0.0115 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0106 | 0.1308 | 0.1308 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 106 nM | Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | ChEMBL. | 18975928 |
Ki (binding) | = 1165 nM | Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | ChEMBL. | 18975928 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.