Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | prolyl oligopeptidase family protein | 0.0168 | 0.2787 | 0.4458 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.6253 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.5977 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.5944 | 0.9945 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0469 | 1 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0056 | 0.0115 | 0.0385 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0056 | 0.0115 | 1 |
Brugia malayi | amidase | 0.0106 | 0.1308 | 0.2092 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0469 | 1 | 1 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0206 | 0.3703 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0056 | 0.0115 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0168 | 0.2787 | 0.2787 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.2993 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0056 | 0.0115 | 0.0115 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0056 | 0.0115 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.2993 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0056 | 0.0115 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.2408 | 0.2408 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0168 | 0.2787 | 0.4664 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.2408 | 0.2408 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.5977 | 0.9558 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0106 | 0.1308 | 0.1308 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.2993 | 0.2993 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0106 | 0.1308 | 0.1308 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0168 | 0.2787 | 0.9312 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0168 | 0.2787 | 0.2787 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0106 | 0.1308 | 0.1308 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1308 | 0.2189 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0056 | 0.0115 | 0.0184 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0056 | 0.0115 | 1 |
Schistosoma mansoni | amidase | 0.0106 | 0.1308 | 0.437 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0469 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.5977 | 0.9558 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0056 | 0.0115 | 0.0311 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0106 | 0.1308 | 0.437 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0106 | 0.1308 | 0.1308 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0168 | 0.2787 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0056 | 0.0115 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.2408 | 0.8044 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 106 nM | Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | ChEMBL. | 18975928 |
Ki (binding) | = 1165 nM | Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | ChEMBL. | 18975928 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.