Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1637 | 0.1637 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.015 | 0.1816 | 0.1816 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0 | 0.5 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0312 | 0.6875 | 0.8809 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.3955 | 0.3955 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0 | 0.5 |
Onchocerca volvulus | 0.0223 | 0.4082 | 0.431 | |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.7311 | 0.7311 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.025 | 0.4925 | 0.5606 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0312 | 0.6875 | 0.7894 |
Onchocerca volvulus | 0.0326 | 0.7311 | 1 | |
Brugia malayi | protein kinase C3,putative | 0.0178 | 0.2711 | 0.3567 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0336 | 0.7601 | 0.7601 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.9756 | 0.9756 |
Onchocerca volvulus | 0.0227 | 0.4233 | 0.4576 | |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.151 | 0.151 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0186 | 0.2934 | 0.2934 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0225 | 0.4157 | 0.4157 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.7311 | 0.7311 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0336 | 0.7601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1637 | 0.1637 |
Schistosoma mansoni | atypical protein kinase C | 0.027 | 0.5549 | 0.4042 |
Echinococcus granulosus | protein kinase C gamma type | 0.0234 | 0.443 | 0.4795 |
Echinococcus multilocularis | protein kinase c iota type | 0.0263 | 0.5326 | 0.6265 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0225 | 0.4157 | 0.5469 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0166 | 0.231 | 0.1313 |
Brugia malayi | Protein kinase c protein 2 | 0.0228 | 0.4261 | 0.5606 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.7311 | 0.7311 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0263 | 0.5326 | 0.6265 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0146 | 0.1712 | 0.1712 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0 | 0.5 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0312 | 0.6875 | 0.8809 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0336 | 0.7601 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0312 | 0.6875 | 0.7894 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0234 | 0.443 | 0.4795 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.4082 | 0.4082 |
Brugia malayi | C1-like domain containing protein | 0.0225 | 0.4157 | 0.5469 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0336 | 0.7601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4233 | 0.4233 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.017 | 0.2461 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0091 | 0 | 0.5 |
Brugia malayi | protein kinase C II. | 0.0336 | 0.7601 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -1 % | Antiinflammatory activity against Swiss mouse assessed as inhibition of arachidonic acid-induced edema at 0.5 mg/ear applied 30 mins before arachidonic acid challenge measured after 1 hr | ChEMBL. | 10217718 |
Inhibition (functional) | = 83 % | Antiinflammatory activity against Swiss mouse assessed as inhibition of TPA-induced edema at 0.5 mg/ear applied simultaneously with TPA measured after 4 hrs | ChEMBL. | 10217718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.