Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated potassium channel | 0.001 | 0.0019 | 0.0234 |
Schistosoma mansoni | NAD dehydrogenase | 0.0148 | 0.0797 | 0.0797 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.178 | 1 | 1 |
Echinococcus granulosus | FAD dependent oxidoreductase domain containing protein | 0.0148 | 0.0797 | 1 |
Echinococcus multilocularis | FAD dependent oxidoreductase domain containing protein | 0.0148 | 0.0797 | 1 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.1632 | 0.9163 | 1 |
Trypanosoma cruzi | FAD dependent oxidoreductase, putative | 0.0148 | 0.0797 | 1 |
Mycobacterium ulcerans | glycerol-3-phosphate dehydrogenase | 0.0148 | 0.0797 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | glycerol-3-phosphate dehydrogenase | 0.0148 | 0.0797 | 0.0797 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.015 | 1 |
Mycobacterium tuberculosis | Possible thiamine biosynthesis oxidoreductase ThiO | 0.0148 | 0.0797 | 0.0806 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0063 | 0.0796 |
Plasmodium vivax | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0148 | 0.0797 | 1 |
Leishmania major | glycerol-3-phosphate dehydrogenase-like protein | 0.0148 | 0.0797 | 1 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0148 | 0.0797 | 1 |
Toxoplasma gondii | FAD-dependent glycerol-3-phosphate dehydrogenase | 0.0148 | 0.0797 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0148 | 0.0797 | 1 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0148 | 0.0797 | 1 |
Schistosoma mansoni | fad oxidoreductase | 0.0148 | 0.0797 | 0.0797 |
Brugia malayi | pyruvate dehydrogenase phosphatase regulatory subunit precursor | 0.0148 | 0.0797 | 1 |
Trypanosoma brucei | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0148 | 0.0797 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0019 | 0.0019 |
Brugia malayi | cDNA sequence BC016226 | 0.0148 | 0.0797 | 1 |
Echinococcus granulosus | glycerol 3 phosphate dehydrogenase | 0.0148 | 0.0797 | 1 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0148 | 0.0797 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0063 | 0.4237 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0163 | 0.2046 |
Schistosoma mansoni | ATP:guanidino kinase (Smc74) | 0.0148 | 0.0797 | 0.0797 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0163 | 0.0163 |
Echinococcus multilocularis | glycerol 3 phosphate dehydrogenase | 0.0148 | 0.0797 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0163 | 0.2046 |
Schistosoma mansoni | d-amino acid oxidase | 0.178 | 1 | 1 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0148 | 0.0797 | 1 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0148 | 0.0797 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0063 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0797 | 0.0797 |
Echinococcus multilocularis | voltage gated potassium channel | 0.001 | 0.0019 | 0.0234 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0063 | 0.4237 |
Plasmodium falciparum | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0148 | 0.0797 | 1 |
Trypanosoma brucei | FAD dependent oxidoreductase, putative | 0.0148 | 0.0797 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0019 | 0.0019 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial | 0.0148 | 0.0797 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0063 | 0.5 |
Schistosoma mansoni | fad oxidoreductase | 0.0148 | 0.0797 | 0.0797 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.001 | 0.0019 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0797 | 0.0797 |
Mycobacterium ulcerans | thiamine biosynthesis oxidoreductase ThiO | 0.0148 | 0.0797 | 0.0738 |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0148 | 0.0797 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0063 | 0.0063 |
Trypanosoma brucei | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0148 | 0.0797 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.001 | 0.0019 | 0.0234 |
Brugia malayi | dimethylglycine dehydrogenase, mitochondrial precursor, putative | 0.0148 | 0.0797 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0063 | 0.0063 |
Schistosoma mansoni | glycerol-3-phosphate dehydrogenase | 0.0148 | 0.0797 | 0.0797 |
Leishmania major | hypothetical protein, conserved | 0.0148 | 0.0797 | 1 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.178 | 1 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 20 | 0.0148 | 0.0797 | 1 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0148 | 0.0797 | 1 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase, putative | 0.0148 | 0.0797 | 1 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0148 | 0.0797 | 1 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0148 | 0.0797 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.015 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.001 | 0.0019 | 0.0234 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0063 | 0.0796 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0163 | 0.2046 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0797 | 0.0797 |
Brugia malayi | RE18450p | 0.0148 | 0.0797 | 1 |
Mycobacterium ulcerans | glycerol-3-phosphate dehydrogenase GlpD2 | 0.0148 | 0.0797 | 0.0738 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0148 | 0.0797 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0063 | 0.0796 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0148 | 0.0797 | 0.5 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0148 | 0.0797 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0019 | 0.0019 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0148 | 0.0797 | 0.0738 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0182 | 0.0182 |
Leishmania major | hypothetical protein, conserved | 0.0148 | 0.0797 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0063 | 0.0063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 262 nmol/L | Antiproliferative activity against human MOLM13 cells after 72 hrs by WST-1 assay | ChEMBL. | 18835166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.