Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.821 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0117 | 0.6505 | 0.6505 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0117 | 0.6505 | 0.6505 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0117 | 0.6505 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0117 | 0.6505 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0051 | 0.1194 | 0.1835 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0756 | 0.0921 |
Schistosoma mansoni | glycogen phosphorylase | 0.0117 | 0.6505 | 0.7923 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0051 | 0.1194 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0756 | 0.0756 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0756 | 0.0756 |
Giardia lamblia | Glycogen phosphorylase | 0.0117 | 0.6505 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0051 | 0.1194 | 0.1835 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0117 | 0.6505 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0117 | 0.6505 | 0.6505 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0117 | 0.6505 | 0.6505 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0756 | 0.0756 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0756 | 0.0756 |
Echinococcus granulosus | glycogen phosphorylase | 0.0117 | 0.6505 | 0.6505 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0756 | 0.0756 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0756 | 0.0921 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0117 | 0.6505 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0051 | 0.1194 | 0.1454 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0756 | 0.0756 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0756 | 0.0921 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.821 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0051 | 0.1194 | 0.5 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0117 | 0.6505 | 0.6505 |
Schistosoma mansoni | glycogen phosphorylase | 0.0117 | 0.6505 | 0.7923 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0051 | 0.1194 | 0.1835 |
Echinococcus granulosus | glycogen phosphorylase | 0.0117 | 0.6505 | 0.6505 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0117 | 0.6505 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0117 | 0.6505 | 0.6505 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0117 | 0.6505 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.