Detailed information for compound 992973

Basic information

Technical information
  • TDR Targets ID: 992973
  • Name: 2-(2-chlorophenyl)-5-methyl-1,3-benzoxazole
  • MW: 243.688 | Formula: C14H10ClNO
  • H donors: 0 H acceptors: 1 LogP: 4.42 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)nc(o2)c1ccccc1Cl
  • InChi: 1S/C14H10ClNO/c1-9-6-7-13-12(8-9)16-14(17-13)10-4-2-3-5-11(10)15/h2-8H,1H3
  • InChiKey: CLKPHBXFLWSHQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STOCK3S-34858
  • 5-Methyl-2-(2-chlorophenyl)benzoxazoles
  • AIDS-097760
  • AIDS097760
  • 2-(2-Chloro-phenyl)-5-methyl-benzooxazole
  • BAS 04380049
  • ZINC00535859

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax importin-beta 2, putative 0.0032 0.0114 0.0341
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0192 0.2115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0192 0.0449
Plasmodium falciparum importin beta, putative 0.0032 0.0114 0.0341
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0274 0.3337 0.5
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0114 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0428 0.0999
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0274 0.3337 0.5
Brugia malayi Importin beta-1 subunit 0.0032 0.0114 0.1253
Loa Loa (eye worm) hypothetical protein 0.0056 0.0428 0.0999
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0032 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0032 1
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0274 0.3337 1
Entamoeba histolytica hypothetical protein 0.0026 0.0032 1
Echinococcus granulosus snurportin 1 0.0345 0.4285 0.4285
Echinococcus multilocularis snurportin 1 0.0345 0.4285 0.4285
Schistosoma mansoni microtubule-associated protein tau 0.0774 1 1
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0274 0.3337 0.5
Schistosoma mansoni importin beta-1 0.0032 0.0114 0.0114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0428 0.4711
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0428 0.4711
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0274 0.3337 1
Brugia malayi RNA, U transporter 1 0.0092 0.0909 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0 0.5
Schistosoma mansoni hypothetical protein 0.0038 0.0192 0.0192
Treponema pallidum hypothetical protein 0.0274 0.3337 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0114 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.4285 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0032 1
Echinococcus granulosus importin subunit beta 1 0.0032 0.0114 0.0114
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0114 1
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0114 0.0114
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0032 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0266
Schistosoma mansoni hypothetical protein 0.0345 0.4285 0.4285
Echinococcus multilocularis microtubule associated protein 2 0.0774 1 1
Leishmania major importin beta-1 subunit, putative 0.0026 0.0032 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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