Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosinase precursor | 0.0299 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0299 | 1 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0296 | 0 | 0.5 |
Onchocerca volvulus | 0.0299 | 1 | 0.5 | |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0299 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0299 | 1 | 1 |
Onchocerca volvulus | 0.0299 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Onchocerca volvulus | 0.0299 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Onchocerca volvulus | 0.0299 | 1 | 0.5 | |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0296 | 0 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0299 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0299 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0299 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0299 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.5 | Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation after 16 hrs by ELISA | ChEMBL. | 21636276 |
IC50 (binding) | = 6.8 | Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation after 16 hrs by ELISA | ChEMBL. | 21636276 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.