Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0189 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0189 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0803 | 0.2791 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0189 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0613 | 0.193 | 0.193 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0189 | 0 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0189 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0189 | 0 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0803 | 0.2791 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0803 | 0.2791 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.193 | 0.193 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2387 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0189 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0803 | 0.2791 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2387 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0803 | 0.2791 | 0.2791 |
Mycobacterium tuberculosis | Probable peptidase | 0.0189 | 0 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0189 | 0 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2387 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0189 | 0 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0803 | 0.2791 | 0.2791 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0189 | 0 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2387 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0189 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0189 | 0 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0849 | 0.3 | 0.3 |
Plasmodium vivax | hypothetical protein, conserved | 0.0189 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2387 | 1 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0803 | 0.2791 | 0.2791 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0189 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0189 | 0 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0803 | 0.2791 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0803 | 0.2791 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0189 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0803 | 0.2791 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 0.05 ug ml-1 | Cytotoxicity against mock-infected human MT4 cells by MTT assay | ChEMBL. | 19091580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.