Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0041 | 0.1763 | 0.0758 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0381 | 0.0381 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0041 | 0.1763 | 0.1763 |
Onchocerca volvulus | 0.0072 | 0.3563 | 0.2966 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1763 | 0.1763 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0214 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0041 | 0.1763 | 0.1763 |
Brugia malayi | LBP/BPI | 0.0031 | 0.1144 | 0.1144 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1763 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1763 | 0.1763 |
Onchocerca volvulus | 0.0072 | 0.3563 | 0.2966 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0072 | 0.3563 | 0.3563 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0041 | 0.1763 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1144 | 0.1144 |
Onchocerca volvulus | 0.0072 | 0.3563 | 0.2966 | |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0167 | 0.4393 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1144 | 0.1144 |
Onchocerca volvulus | 0.0072 | 0.3563 | 0.2966 | |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.9298 | 1 |
Onchocerca volvulus | 0.0072 | 0.3563 | 0.2966 | |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3563 | 0.3563 |
Onchocerca volvulus | 0.0072 | 0.3563 | 0.2966 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0072 | 0.3563 | 0.3563 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0072 | 0.3563 | 0.3563 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0072 | 0.3563 | 0.3563 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1763 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0381 | 0.0381 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0167 | 0.4393 |
Onchocerca volvulus | 0.0072 | 0.3563 | 0.2966 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1144 | 0.1144 |
Onchocerca volvulus | 0.0072 | 0.3563 | 0.2966 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0041 | 0.1763 | 0.1763 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0167 | 0.7834 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0167 | 0.4393 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1763 | 0.1763 |
Brugia malayi | hypothetical protein | 0.0031 | 0.1144 | 0.1144 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1144 | 0.1144 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0381 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 0.9071 | 0.9722 | |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0381 | 1 |
Onchocerca volvulus | 0.0041 | 0.1763 | 0.0758 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.1144 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0214 | 0.5607 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0041 | 0.1763 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1763 | 0.1763 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1763 | 0.1763 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | Inhibition of KDR | ChEMBL. | 18573658 |
IC50 (functional) | = 6 nM | Antiproliferative activity against VEGF-induced HUVEC | ChEMBL. | 18573658 |
IC50 (functional) | > 1140 nM | Antiproliferative activity against FGF-induced HUVEC | ChEMBL. | 18573658 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18573658 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.