Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor III (thromboplastin, tissue factor) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor VII (serum prothrombin conversion accelerator) | References | |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | glycoprotein Antigen 5 | coagulation factor VII (serum prothrombin conversion accelerator) | 466 aa | 384 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0232 | 0.0815 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.1764 | 1 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0232 | 0.0815 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0232 | 0.0815 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0232 | 0.0815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0815 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.1764 | 1 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0232 | 0.0815 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0232 | 0.0815 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0232 | 0.0815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0815 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0232 | 0.0815 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.1532 | 0.8608 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0232 | 0.0815 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0232 | 0.0815 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0232 | 0.0815 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0232 | 0.0815 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0232 | 0.0815 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0232 | 0.0815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0815 | 0.5 |
Onchocerca volvulus | 0.0232 | 0.0815 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0815 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0232 | 0.0815 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.1764 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0815 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.1532 | 0.8608 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.1764 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of plasmin | ChEMBL. | 19409795 | |
IC50 (binding) | = 0.009 nM | Inhibition of tissue factor/factor 7a | ChEMBL. | 19409795 |
IC50 (binding) | = 0.009 uM | Inhibition of tissue factor/factor 7a | ChEMBL. | 19409795 |
IC50 (binding) | = 1.65 uM | Inhibition of factor 10a | ChEMBL. | 19409795 |
IC50 (binding) | = 9.4 uM | Inhibition of thrombin | ChEMBL. | 19409795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.