Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0063 | 0.0846 | 1 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.003 | 0.0189 | 0.0189 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0235 | 0.2169 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0114 | 1 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.003 | 0.0189 | 0.0189 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0235 | 0.0235 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0063 | 0.0846 | 0.0846 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0063 | 0.0846 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0345 | 0.6439 | 0.6439 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0066 | 0.5 |
Onchocerca volvulus | 0.003 | 0.0189 | 0.0552 | |
Brugia malayi | prostaglandin transporter | 0.003 | 0.0189 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0189 | 0.0293 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0024 | 0.0066 | 0.0172 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0257 | 0.0257 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.003 | 0.0189 | 0.0325 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0235 | 0.2169 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0188 | 0.3319 | 0.3319 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0257 | 0.0257 |
Trypanosoma cruzi | MFS transporter, putative | 0.003 | 0.0189 | 0.157 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0189 | 0.0293 |
Onchocerca volvulus | 0.003 | 0.0189 | 0.0552 | |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0257 | 0.0257 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0188 | 0.3319 | 0.5716 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0345 | 0.6439 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0114 | 0.0615 |
Schistosoma mansoni | hypothetical protein | 0.0525 | 1 | 1 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0313 | 0.5807 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.6439 | 0.6439 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.1026 | 0.1767 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0114 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0551 | 0.0856 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0235 | 0.0405 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.1689 | 0.2908 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0214 | 0.3845 | 1 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0066 | 0.0114 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0024 | 0.0066 | 0.0066 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0188 | 0.3319 | 0.972 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0235 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.1689 | 0.2908 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0063 | 0.0846 | 0.0846 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0235 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.003 | 0.0189 | 0.0552 |
Echinococcus multilocularis | geminin | 0.0525 | 1 | 1 |
Schistosoma mansoni | organic anion transporter | 0.003 | 0.0189 | 0.0189 |
Brugia malayi | RNA, U transporter 1 | 0.0092 | 0.1417 | 0.2441 |
Echinococcus granulosus | snurportin 1 | 0.0345 | 0.6439 | 0.6439 |
Schistosoma mansoni | hypothetical protein | 0.0525 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0235 | 0.0365 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0063 | 0.0846 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0063 | 0.0846 | 0.1458 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0063 | 0.0846 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0188 | 0.3319 | 0.3319 |
Schistosoma mansoni | organic anion transporter | 0.003 | 0.0189 | 0.0189 |
Brugia malayi | hypothetical protein | 0.003 | 0.0189 | 0.0325 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0063 | 0.0846 | 0.2201 |
Loa Loa (eye worm) | STAT protein | 0.0313 | 0.5807 | 0.9018 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0024 | 0.0066 | 0.0066 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.003 | 0.0189 | 0.0325 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.003 | 0.0189 | 0.0189 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0189 | 0.0293 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0235 | 0.0235 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0257 | 0.0257 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0114 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0257 | 0.0257 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0235 | 0.0612 |
Brugia malayi | hypothetical protein | 0.003 | 0.0189 | 0.0325 |
Schistosoma mansoni | ran | 0.0024 | 0.0066 | 0.0066 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0193 | 0.3415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0189 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1026 | 0.1594 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0257 | 0.0399 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0188 | 0.3319 | 0.5155 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0257 | 0.0442 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.1689 | 0.2623 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0188 | 0.3319 | 0.3319 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0235 | 0.0235 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.003 | 0.0189 | 0.049 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0189 | 0.0293 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.003 | 0.0189 | 0.0189 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0066 | 0.0103 |
Onchocerca volvulus | Putative organic anion transporter | 0.003 | 0.0189 | 0.0552 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0257 | 0.0257 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0114 | 1 |
Onchocerca volvulus | 0.003 | 0.0189 | 0.0552 | |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0114 | 0.0615 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0257 | 0.0399 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0257 | 0.0257 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0551 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.3415 | 0.5303 |
Onchocerca volvulus | 0.003 | 0.0189 | 0.0552 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0189 | 0.0293 |
Onchocerca volvulus | 0.003 | 0.0189 | 0.0552 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0257 | 0.0442 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0063 | 0.0846 | 1 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.003 | 0.0189 | 0.0325 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.1026 | 0.1026 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0063 | 0.0846 | 0.0846 |
Schistosoma mansoni | ran | 0.0024 | 0.0066 | 0.0066 |
Onchocerca volvulus | Putative organic anion transporter | 0.003 | 0.0189 | 0.0552 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.003 | 0.0189 | 0.0293 |
Brugia malayi | N-terminal motif family protein | 0.0193 | 0.3415 | 0.588 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0189 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1689 | 0.2623 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy | ChEMBL. | 18835718 | |
Activity (binding) | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy | ChEMBL. | 18835718 | |
Activity (binding) | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy | ChEMBL. | 18835718 | |
Activity (binding) | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy | ChEMBL. | 18835718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.