Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.051 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0464 | 0.8354 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0064 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.062 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0556 | 0.0769 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0064 | 0.1028 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0064 | 0.1145 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0064 | 0.1145 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0178 | 0.2632 | 0.5 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0064 | 0.1145 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0178 | 0.2632 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.051 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0064 | 0.0088 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0556 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0474 | 0.7231 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0178 | 0.2632 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0178 | 0.2632 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0178 | 0.2632 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0556 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0178 | 0.2632 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0178 | 0.2632 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.062 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0178 | 0.2632 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0064 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0064 | 0.1028 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0556 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23 nM | Displacement of [35S]MK499 from human ERG expressed in HEK293 cells | ChEMBL. | 19447610 |
IC50 (binding) | = 350 nM | Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptor | ChEMBL. | 19447610 |
IC50 (functional) | = 480 nM | Antagonist activity at ORL1 receptor expressed in CHO cells assessed as inhibition of NC/OFQ-stimulated [35S]GTPgammaS binding | ChEMBL. | 19447610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.