Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | D-amino-acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 378 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ets-domain containing protein | 0.008 | 0.1724 | 0.2282 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0192 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 0.4502 | 0.4394 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.008 | 0.1724 | 0.1562 |
Brugia malayi | RNA, U transporter 1 | 0.009 | 0.2061 | 0.2783 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0192 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5393 | 0.5302 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4502 | 0.4394 |
Schistosoma mansoni | gabp alpha | 0.008 | 0.1724 | 0.1562 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.008 | 0.1724 | 0.1562 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0192 | 0.5 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0 | 0.5 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1355 | 0.1186 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0192 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0339 | 1 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0195 | 0.5393 | 0.5 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0192 | 0.5 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | GA binding protein alpha chain | 0.008 | 0.1724 | 0.1562 |
Schistosoma mansoni | ets-related | 0.0242 | 0.6907 | 0.6847 |
Brugia malayi | Ets-domain containing protein | 0.008 | 0.1724 | 0.2282 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0339 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.4502 | 0.4394 |
Echinococcus multilocularis | snurportin 1 | 0.0339 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0195 | 0.5393 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0179 | 0.4875 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.0195 | 0.5393 | 0.5302 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4502 | 0.4394 |
Loa Loa (eye worm) | fli-1 protein | 0.0242 | 0.6907 | 0.6847 |
Brugia malayi | Fli-1 protein | 0.0242 | 0.6907 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 516 nM | Inhibition of human DAO | ChEMBL. | 18455394 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.