Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hypocretin (orexin) receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | hypocretin (orexin) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | G protein coupled receptor 139 | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus granulosus | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma mansoni | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | sex peptide receptor | hypocretin (orexin) receptor 1 | 425 aa | 350 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glycogen phosphorylase | 0.023 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.023 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.023 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.023 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.023 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.023 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.023 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.023 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.023 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.023 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.023 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.023 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.023 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.023 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.023 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.023 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 239 nM | Inhibition of human OX2 receptor expressed in CHO cells assessed as intercellular calcium mobilization by FLIPR assay | ChEMBL. | 18845436 |
IC50 (functional) | > 10000 nM | Inhibition of human OX1 receptor expressed in CHO cells assessed as intercellular calcium mobilization by FLIPR assay | ChEMBL. | 18845436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.