Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acyl-CoA desaturase | 0.0611 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0611 | 0 | 0.5 |
Onchocerca volvulus | 0.0676 | 1 | 0.5 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0611 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0676 | 1 | 0.5 |
Onchocerca volvulus | 0.0676 | 1 | 0.5 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0676 | 1 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0676 | 1 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0611 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 150 ug ml-1 | Antimicrobial activity against Candida albicans after 24 hrs by disk diffusion method | ChEMBL. | 12398535 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.