Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0188 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0204 | 1 | 0.5 |
Onchocerca volvulus | 0.0204 | 1 | 0.5 | |
Brugia malayi | acyl-CoA desaturase | 0.0188 | 0 | 0.5 |
Onchocerca volvulus | 0.0204 | 1 | 0.5 | |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0188 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0188 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0204 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0204 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 100 uM | Growth inhibition of human K562 cells expressing p210Bcr/Abl after 96 hrs by trypan blue exclusion assay | ChEMBL. | 20188579 |
GI50 (functional) | > 100 uM | Growth inhibition of human DU145 cells after 96 hrs by trypan blue exclusion assay | ChEMBL. | 20188579 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.