Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | fatty-acid desaturase, putative | 0.0202 | 1 | 0.5 |
Onchocerca volvulus | 0.0202 | 1 | 0.5 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0186 | 0 | 0.5 |
Onchocerca volvulus | 0.0202 | 1 | 0.5 | |
Brugia malayi | acyl-CoA desaturase | 0.0186 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0186 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0186 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0202 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0202 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimalarial activity as survivor numbers against multidrug-resistant Plasmodium yoelii nigeriensis infected Swiss mice (Mus musculus) at 96 mg/kg intramuscular dose at day 28 | ChEMBL. | 18789862 | |
Activity (functional) | Antimalarial activity as survivor numbers against multidrug-resistant Plasmodium yoelii nigeriensis infected Swiss mice (Mus musculus) at 96 mg/kg peroral dose at day 28 | ChEMBL. | 18789862 | |
Activity (functional) | = 50 % | Antimalarial activity as reduced parasitaemia against multidrug-resistant Plasmodium yoelii nigeriensis infected Swiss mice (Mus musculus) at 96 mg/kg intramuscular dose at day 4 | ChEMBL. | 18789862 |
Activity (functional) | = 63.18 % | Antimalarial activity as reduced parasitaemia against multidrug-resistant Plasmodium yoelii nigeriensis infected Swiss mice (Mus musculus) at 96mg/kg peroral dose at day 4 | ChEMBL. | 18789862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.