Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.04 | 0.5942 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0368 | 0.5392 | 0.5392 |
Leishmania major | fatty-acid desaturase, putative | 0.04 | 0.5942 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0368 | 0.5392 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0368 | 0.5392 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0639 | 1 | 1 |
Onchocerca volvulus | 0.04 | 0.5942 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0639 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0508 | 0.7778 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0639 | 1 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.04 | 0.5942 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0639 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0639 | 1 | 1 |
Onchocerca volvulus | 0.04 | 0.5942 | 1 | |
Brugia malayi | acyl-CoA desaturase | 0.0368 | 0.5392 | 0.6932 |
Leishmania major | stearic acid desaturase, putative | 0.04 | 0.5942 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | Displacement of [3H]flumazenil from rat GABA-A alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cells | ChEMBL. | 19469479 | |
Ki (binding) | Displacement of [3H]flumazenil from rat GABA-A alpha-2-beta-2-gamma-2 receptor expressed in HEK293 cells | ChEMBL. | 19469479 | |
Ki (binding) | Displacement of [3H]flumazenil from rat GABA-A alpha-5-beta-3-gamma-2 receptor expressed in HEK293 cells | ChEMBL. | 19469479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.