Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 7 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 502 aa | 513 aa | 33.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2156 | 0.3293 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0209 | 0.6549 | 1 |
Onchocerca volvulus | 0.0209 | 0.6549 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0209 | 0.6549 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0294 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0294 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.2111 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0294 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0085 | 0.1536 | 0.2345 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1875 | 0.2863 |
Brugia malayi | hypothetical protein | 0.0099 | 0.2111 | 0.1148 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0085 | 0.1536 | 0.2345 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0294 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0209 | 0.6549 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0209 | 0.6549 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2156 | 0.3293 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0139 | 0.3733 | 0.57 |
Echinococcus granulosus | thymidylate synthase | 0.0209 | 0.6549 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 0.2156 | 0.3293 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0099 | 0.2111 | 0.1148 |
Brugia malayi | Cation transporter family protein | 0.0101 | 0.2156 | 0.1238 |
Echinococcus granulosus | dihydrofolate reductase | 0.0085 | 0.1536 | 0.2345 |
Brugia malayi | thymidylate synthase | 0.0209 | 0.6549 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0209 | 0.6549 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0085 | 0.1536 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 0.2156 | 0.3293 |
Echinococcus multilocularis | thymidylate synthase | 0.0209 | 0.6549 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0085 | 0.1536 | 0.2345 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0294 | 1 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0139 | 0.3733 | 0.57 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 10.5 uM | Allosteric modulator activity at alpha7 nAChR in human IMR32 cells assessed as stimulation of agonist-induced intracellular calcium level by FLIPR assay | ChEMBL. | 19419141 |
Efficacy (functional) | = 26 % | Allosteric modulator activity at alpha7 nAChR in human IMR32 cells assessed as stimulation of agonist-induced intracellular calcium level by FLIPR assay relative to 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea | ChEMBL. | 19419141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.