Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0109 | 0.2817 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2689 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.2689 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0109 | 0.2817 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2689 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2689 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0729 | 0.2589 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 1 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Plasmodium falciparum | peptide deformylase | 0.0279 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.2689 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0043 | 0 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0729 | 0.2589 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0729 | 0.2589 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2689 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.2689 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0109 | 0.2817 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0729 | 0.2589 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30 nM | Inhibition of Escherichia coli nickel containing peptide deformylase | ChEMBL. | 21621999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.