Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | D-amino-acid oxidase | Starlite/ChEMBL | References |
Homo sapiens | D-amino-acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Unconventional prefoldin RPB5 interactor 1 homolog | D-amino-acid oxidase | 346 aa | 350 aa | 31.1 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 346 aa | 382 aa | 24.1 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 378 aa | 24.6 % |
Candida albicans | similar to putative d-amino acid oxidase | D-amino-acid oxidase | 346 aa | 388 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.039 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0278 | 0.6752 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0357 | 0.9053 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | glutaminase | 0.0278 | 0.6752 | 0.6752 |
Brugia malayi | glutaminase DH11.1 | 0.0278 | 0.6752 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0278 | 0.6752 | 0.6752 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.039 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0278 | 0.6752 | 0.6752 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.039 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8 nM | Inhibition of human recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay | ChEMBL. | 19438227 |
IC50 (binding) | = 196 nM | Inhibition of rat recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay | ChEMBL. | 19438227 |
IC50 (binding) | = 64000 nM | Inhibition of human recombinant DDO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay | ChEMBL. | 19438227 |
Kd (binding) | = 18 nM | Binding affinity to biotinylated human recombinant DAAO by Biacore assay | ChEMBL. | 19438227 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.