Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0753 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0246 | 0.0878 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1666 | 0.1666 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1476 | 0.5263 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0246 | 0.0878 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0013 | 0.0006 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0246 | 0.0246 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0753 | 0.2687 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0227 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0753 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.2804 | 1 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0227 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.2078 | 0.7412 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.2804 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1637 | 0.1637 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0246 | 0.0878 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1637 | 0.1637 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0753 | 0.2687 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0227 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1666 | 0.1666 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0246 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0246 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.123 | 0.123 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0227 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0753 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0246 | 0.0246 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1637 | 0.1637 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.2804 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0227 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.2078 | 0.7412 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.2804 | 0.2804 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2804 | 0.2804 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.2804 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1637 | 0.5838 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0227 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.2804 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1637 | 0.1637 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2078 | 0.7412 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1201 | 0.4285 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0246 | 0.0246 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0227 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0073 | 0.2804 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0246 | 0.0246 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1476 | 0.5263 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0013 | 0.0006 | 0.0006 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0753 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1637 | 0.1637 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2804 | 0.2804 |
Schistosoma mansoni | hypothetical protein | 0.0227 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1637 | 0.1637 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0246 | 0.0246 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.123 | 0.4388 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0227 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.2078 | 0.7412 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0246 | 0.0246 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0227 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.2804 | 0.2804 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1476 | 0.1476 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0246 | 0.0878 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.123 | 0.4388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2804 | 0.2804 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2804 | 0.2804 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0273 | 0.0974 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0227 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1637 | 0.5838 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0227 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1476 | 0.1476 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1637 | 0.1637 |
Giardia lamblia | Rrm3p helicase | 0.0227 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2804 | 0.2804 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.221849 | Inhibition of human ERG channel | ChEMBL. | 19534531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.