Target list

Search results for query: Weighted list for comparison of PLOS-NTD's vs. this B. malayi targets prioritization

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #35 (Bma - larval/adult lethal/arrest in Cel): 40
  • Score for genes in query #29 (Bma - sterile in Cel): 20
  • Score for genes in query #32 (Bma in Cel): 10
  • Score for genes in query #34 (Bma - growth defect in Cel): 20
  • Score for genes in query #27 (B. malayi orthologs of C. elegans genes differentially expressed in neurons): 30
  • Score for genes in query #38 (Bma any EC): 10
  • Score for genes in query #23 (B. malayi orthologs of C. elegans genes differentially expressed in muscle): 30
  • Score for genes in query #31 (Bma pubmed): 2
  • Score for genes in query #40 (Bma assayable): 5
  • Score for genes in query #36 (Bma - morphology defect in Cel): 20
  • Score for genes in query #44 ( top-25 of ranked list for PLOS-NTD; Posted List 361, No tissue-differential gene expression data): 0
  • Score for genes in query #39 (Bma in PDB): 5
  • Score for genes in query #41 (Bma all proteins): 1
  • Score for genes in query #30 (Bma modbase): 2
  • Score for genes in query #37 (Bma any essentiality): 5
  • Score for genes in query #33 (Bma - embryonic lethal/arrest in Cel): 30
  • Score for genes in query #28 (Bma druggable precedence by similarity to starlite targets): 30
  • Score for genes in query #45 ( top-100 of ranked list for PLOS-NTD; Posted List 361, No tissue-differential gene expression data): 0

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

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11305 records found | Showing page 1 of 453 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
B. malayi   Bm1_44630   OG5_126812   oxidoreductase, short chain dehydrogenase/reductase family protein 208
B. malayi   Bm1_20715   OG5_126605   tubulin alpha-2 chain 208
B. malayi   Bm1_38680   OG5_126605   tubulin alpha chain - mouse 208
B. malayi   Bm1_14145   OG5_127382   protein phosphatase PP2A regulatory subunit 208
B. malayi   Bm1_12120   OG5_126605   alpha-tubulin 208
B. malayi   Bm1_55400   OG5_126605   Tubulin alpha-2 chain 208
B. malayi   Bm1_43680   OG5_127998   T-complex protein 1, alpha subunit 208
B. malayi   Bm1_25035   OG5_126605   Tubulin alpha-2 chain 208
B. malayi   Bm1_30260   OG5_126605   Tubulin alpha chain 208
B. malayi   Bm1_24575   OG5_126762   adenylate kinase isoenzyme 1 203
B. malayi   Bm1_17330   OG5_126927   succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 198
B. malayi   Bm1_12875   OG5_126821   Serine/threonine protein phosphatase PP1-beta catalytic subunit 198
B. malayi   Bm1_38390   OG5_127141   protein phosphatase 2A. 198
B. malayi   Bm1_48165   OG5_127233   Adenosylhomocysteinase 198
B. malayi   Bm1_41940   OG5_126628   Glyceraldehyde 3-phosphate dehydrogenase 198
B. malayi   Bm1_19675   OG5_126821   Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 198
B. malayi   Bm1_35945   OG5_128520   Protein kinase domain containing protein 190
B. malayi   Bm1_39715   OG5_126623   Endoplasmin precursor 188
B. malayi   Bm1_17890   OG5_127832   T-complex protein 1, delta subunit 188
B. malayi   Bm1_17325   OG5_126927   succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 188
B. malayi   Bm1_44415   OG5_192700   Neurotransmitter-gated ion-channel ligand binding domain containing protein 188
B. malayi   Bm1_16810   OG5_126595   actin 188
B. malayi   Bm1_34710   OG5_127093   FAD linked oxidases, C-terminal domain containing protein 188
B. malayi   Bm1_25205   OG5_127407   leucyl-tRNA synthetase 188
B. malayi   Bm1_46445   OG5_126705   vacuolar proton pump 188