pI: 6.058 |
Length (AA): 475 |
MW (Da): 52185 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Bloodstream Form. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127342)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_37280 | hypothetical protein |
Candida albicans | CaO19.11397 | similar to S. cerevisiae YFR044C |
Candida albicans | CaO19.3915 | similar to S. cerevisiae YFR044C |
Caenorhabditis elegans | CELE_Y71H2AM.11 | Protein Y71H2AM.11 |
Caenorhabditis elegans | CELE_R11H6.1 | Protein PES-9 |
Dictyostelium discoideum | DDB_G0279291 | hypothetical protein |
Drosophila melanogaster | Dmel_CG17337 | CG17337 gene product from transcript CG17337-RA |
Echinococcus granulosus | EgrG_000992300 | cytosolic non specific dipeptidase |
Echinococcus multilocularis | EmuJ_000992300 | cytosolic non specific dipeptidase |
Homo sapiens | ENSG00000133313 | CNDP dipeptidase 2 (metallopeptidase M20 family) |
Homo sapiens | ENSG00000150656 | carnosine dipeptidase 1 (metallopeptidase M20 family) |
Leishmania braziliensis | LbrM.33.1880 | peptidase M20/M25/M40, putative |
Leishmania braziliensis | LbrM.31.2100 | peptidase m20/m25/m40 family-like protein |
Leishmania braziliensis | LbrM.31.2120 | peptidase m20/m25/m40 family-like protein |
Leishmania braziliensis | LbrM.33.2100 | peptidase M20/M25/M40, putative |
Leishmania braziliensis | LbrM.31.2280 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania donovani | LdBPK_331710.1 | cytosolic nonspecific dipeptidase, putative |
Leishmania donovani | LdBPK_312060.1 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania infantum | LinJ.33.1710 | peptidase M20/M25/M40, putative |
Leishmania infantum | LinJ.31.2060 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania major | LmjF.33.1610 | peptidase M20/M25/M40, putative |
Leishmania major | LmjF.31.1890 | peptidase m20/m25/m40 family-like protein |
Leishmania major | LmjF.31.2020 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania mexicana | LmxM.30.2020 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania mexicana | LmxM.30.1890 | peptidase m20/m25/m40 family-like protein |
Leishmania mexicana | LmxM.32.1610 | peptidase M20/M25/M40, putative |
Loa Loa (eye worm) | LOAG_10052 | cytosolic non-specific dipeptidase |
Mycobacterium leprae | ML1193 | conserved hypothetical protein |
Mus musculus | ENSMUSG00000024644 | CNDP dipeptidase 2 (metallopeptidase M20 family) |
Mus musculus | ENSMUSG00000056162 | carnosine dipeptidase 1 (metallopeptidase M20 family) |
Mycobacterium tuberculosis | Rv2522c | Conserved hypothetical protein |
Mycobacterium ulcerans | MUL_3812 | hypothetical protein |
Saccharomyces cerevisiae | YFR044C | metallodipeptidase |
Schmidtea mediterranea | mk4.025490.00 | |
Schmidtea mediterranea | mk4.033352.00 | |
Schmidtea mediterranea | mk4.003046.02 | |
Schmidtea mediterranea | mk4.010005.00 | |
Trypanosoma brucei gambiense | Tbg972.10.14780 | cytosolic nonspecific dipeptidase, putative,peptidase (M20/M25/M40 family), putative |
Trypanosoma brucei gambiense | Tbg972.6.80 | peptidase M20/M25/M40, putative |
Trypanosoma brucei | Tb927.6.400 | peptidase M20/M25/M40, putative |
Trypanosoma brucei | Tb927.10.12260 | cytosolic nonspecific dipeptidase, putative |
Trypanosoma congolense | TcIL3000_10_10490 | cytosolic nonspecific dipeptidase, putative |
Trypanosoma cruzi | TcCLB.510257.80 | cytosolic nonspecific dipeptidase, putative |
Trypanosoma cruzi | TcCLB.509213.120 | cytosolic nonspecific dipeptidase, putative |
Toxoplasma gondii | TGME49_213060 | WD domain, G-beta repeat-containing protein |
Trichomonas vaginalis | TVAG_370490 | Clan MH, family M20, peptidase T-like metallopeptidase |
Trichomonas vaginalis | TVAG_224980 | Clan MH, family M20, peptidase T-like metallopeptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.400 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.400 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.400 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.400 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.12260 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.12260 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.12260 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.12260 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_213060 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.