pI: 6.9496 |
Length (AA): 3086 |
MW (Da): 328240 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 11 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1895 | 2187 | 1nex (B) | 372 | 692 | 19.00 | 0 | 0.94 | 0.23 | 0.84 |
3 | 370 | 4zfl (A) | 3 | 230 | 25.00 | 0 | 0.76 | -0.311452 | 1.32 |
119 | 360 | 3mdn (A) | 45 | 248 | 30.00 | 0 | 0.99 | 0.0507187 | 0.82 |
125 | 315 | 3mdn (A) | 51 | 199 | 31.00 | 0 | 0.95 | -0.0824076 | 1.27 |
365 | 506 | 3knz (A) | 0 | 132 | 14.00 | 0.13 | 0.11 | 0.153314 | -0.11 |
1687 | 1836 | 4cou (A) | 118 | 257 | 9.00 | 0 | 0 | 0.0643066 | -0.29 |
1983 | 2041 | 2hes (X) | 164 | 226 | 41.00 | 0.22 | 0.99 | 0.405519 | 0.53 |
1986 | 2045 | 4cy3 (A) | 128 | 187 | 35.00 | 0.08 | 0.81 | 0.428843 | 0.12 |
2466 | 2972 | 3dlj (A) | 72 | 441 | 34.00 | 0 | 1 | 0.11969 | 0.85 |
2471 | 3081 | 2zog (A) | 72 | 474 | 31.00 | 0 | 1 | -0.0803091 | 1.36 |
2929 | 3015 | 1q7l (B) | 321 | 408 | 11.00 | 0.0014 | 0.01 | -0.0465082 | 0.91 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst. | Gregory Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 merozoite, ME49 Bradyzoite. | Hehl AB Sibley/Greg |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_127342)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_37280 | hypothetical protein |
Candida albicans | CaO19.11397 | similar to S. cerevisiae YFR044C |
Candida albicans | CaO19.3915 | similar to S. cerevisiae YFR044C |
Caenorhabditis elegans | CELE_Y71H2AM.11 | Protein Y71H2AM.11 |
Caenorhabditis elegans | CELE_R11H6.1 | Protein PES-9 |
Dictyostelium discoideum | DDB_G0279291 | hypothetical protein |
Drosophila melanogaster | Dmel_CG17337 | CG17337 gene product from transcript CG17337-RA |
Echinococcus granulosus | EgrG_000992300 | cytosolic non specific dipeptidase |
Echinococcus multilocularis | EmuJ_000992300 | cytosolic non specific dipeptidase |
Homo sapiens | ENSG00000133313 | CNDP dipeptidase 2 (metallopeptidase M20 family) |
Homo sapiens | ENSG00000150656 | carnosine dipeptidase 1 (metallopeptidase M20 family) |
Leishmania braziliensis | LbrM.33.1880 | peptidase M20/M25/M40, putative |
Leishmania braziliensis | LbrM.31.2100 | peptidase m20/m25/m40 family-like protein |
Leishmania braziliensis | LbrM.31.2120 | peptidase m20/m25/m40 family-like protein |
Leishmania braziliensis | LbrM.33.2100 | peptidase M20/M25/M40, putative |
Leishmania braziliensis | LbrM.31.2280 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania donovani | LdBPK_331710.1 | cytosolic nonspecific dipeptidase, putative |
Leishmania donovani | LdBPK_312060.1 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania infantum | LinJ.33.1710 | peptidase M20/M25/M40, putative |
Leishmania infantum | LinJ.31.2060 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania major | LmjF.33.1610 | peptidase M20/M25/M40, putative |
Leishmania major | LmjF.31.1890 | peptidase m20/m25/m40 family-like protein |
Leishmania major | LmjF.31.2020 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania mexicana | LmxM.30.2020 | succinyl-diaminopimelate desuccinylase-like protein |
Leishmania mexicana | LmxM.30.1890 | peptidase m20/m25/m40 family-like protein |
Leishmania mexicana | LmxM.32.1610 | peptidase M20/M25/M40, putative |
Loa Loa (eye worm) | LOAG_10052 | cytosolic non-specific dipeptidase |
Mycobacterium leprae | ML1193 | conserved hypothetical protein |
Mus musculus | ENSMUSG00000024644 | CNDP dipeptidase 2 (metallopeptidase M20 family) |
Mus musculus | ENSMUSG00000056162 | carnosine dipeptidase 1 (metallopeptidase M20 family) |
Mycobacterium tuberculosis | Rv2522c | Conserved hypothetical protein |
Mycobacterium ulcerans | MUL_3812 | hypothetical protein |
Saccharomyces cerevisiae | YFR044C | metallodipeptidase |
Schmidtea mediterranea | mk4.025490.00 | |
Schmidtea mediterranea | mk4.033352.00 | |
Schmidtea mediterranea | mk4.003046.02 | |
Schmidtea mediterranea | mk4.010005.00 | |
Trypanosoma brucei gambiense | Tbg972.10.14780 | cytosolic nonspecific dipeptidase, putative,peptidase (M20/M25/M40 family), putative |
Trypanosoma brucei gambiense | Tbg972.6.80 | peptidase M20/M25/M40, putative |
Trypanosoma brucei | Tb927.6.400 | peptidase M20/M25/M40, putative |
Trypanosoma brucei | Tb927.10.12260 | cytosolic nonspecific dipeptidase, putative |
Trypanosoma congolense | TcIL3000_10_10490 | cytosolic nonspecific dipeptidase, putative |
Trypanosoma cruzi | TcCLB.510257.80 | cytosolic nonspecific dipeptidase, putative |
Trypanosoma cruzi | TcCLB.509213.120 | cytosolic nonspecific dipeptidase, putative |
Toxoplasma gondii | TGME49_213060 | WD domain, G-beta repeat-containing protein |
Trichomonas vaginalis | TVAG_370490 | Clan MH, family M20, peptidase T-like metallopeptidase |
Trichomonas vaginalis | TVAG_224980 | Clan MH, family M20, peptidase T-like metallopeptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.400 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.400 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.400 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.400 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.12260 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.12260 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.12260 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.12260 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_213060 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.