pI: 8.3572 |
Length (AA): 414 |
MW (Da): 45905 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128444)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G18230 | hypothetical protein |
Babesia bovis | BBOV_IV004090 | conserved membrane protein, putative |
Brugia malayi | Bm1_52490 | cap8F |
Candida albicans | CaO19.12823 | similar to S. cerevisiae YBR070C |
Candida albicans | CaO19.5363 | similar to S. cerevisiae YBR070C |
Caenorhabditis elegans | CELE_M02B7.4 | Protein HPO-16 |
Cryptosporidium hominis | Chro.70549 | hypothetical protein |
Cryptosporidium parvum | cgd7_4930 | secreted glycosyltransferase, possible transmembrane domain near C-terminus |
Dictyostelium discoideum | DDB_G0290339 | hypothetical protein |
Drosophila melanogaster | Dmel_CG6308 | CG6308 gene product from transcript CG6308-RA |
Echinococcus granulosus | EgrG_000865200 | UDP N acetylglucosamine transferase subunit |
Entamoeba histolytica | EHI_049660 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000865200 | UDP N acetylglucosamine transferase subunit |
Homo sapiens | 199857 | ALG14, UDP-N-acetylglucosaminyltransferase subunit |
Leishmania braziliensis | LbrM.30.0610 | glycosyltransferase family 28 protein, putative |
Leishmania donovani | LdBPK_300550.1 | glycosyltransferase family 28 protein, putative |
Leishmania infantum | LinJ.30.0550 | glycosyltransferase family 28 protein, putative |
Leishmania major | LmjF.30.0530 | glycosyltransferase family 28 protein, putative |
Leishmania mexicana | LmxM.29.0530 | glycosyltransferase family 28 protein, putative |
Mus musculus | ENSMUSG00000039887 | asparagine-linked glycosylation 14 |
Neospora caninum | NCLIV_052990 | Glycosyltransferase family protein, related |
Oryza sativa | 4333143 | Os03g0423200 |
Plasmodium berghei | PBANKA_0308400 | UDP-N-acetylglucosamine transferase subunit ALG14, putative |
Plasmodium falciparum | PF3D7_0211600 | UDP-N-acetylglucosamine transferase subunit ALG14, putative |
Plasmodium knowlesi | PKNH_0409600 | UDP-N-acetylglucosamine transferase subunit ALG14, putative |
Plasmodium vivax | PVX_002950 | hypothetical protein, conserved |
Plasmodium yoelii | PY04598 | glycosyl transferase |
Saccharomyces cerevisiae | YBR070C | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14 |
Schistosoma japonicum | Sjp_0094960 | ko:K07441 beta-1,4-N-acetylglucosaminyltransferase, putative |
Schistosoma mansoni | Smp_045430.1 | glycosyltransferase-related |
Schistosoma mansoni | Smp_045430.3 | glycosyltransferase-related |
Schmidtea mediterranea | mk4.001668.05 | |
Trypanosoma brucei gambiense | Tbg972.6.1680 | glycosyltransferase family 28 protein, putative |
Trypanosoma brucei | Tb927.6.1960 | glycosyltransferase family 28 protein, putative |
Trypanosoma congolense | TcIL3000_6_1540 | glycosyltransferase family 28 protein, putative |
Trypanosoma cruzi | TcCLB.504071.90 | glycosyltransferase family 28 protein, putative |
Toxoplasma gondii | TGME49_207070 | glycosyl transferase, putative |
Trichomonas vaginalis | TVAG_038800 | glycosyl transferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.1960 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.1960 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.1960 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.1960 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
YBR070C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0308400 | Plasmodium berghei | Slow | plasmo |
TGME49_207070 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
1 literature reference was collected for this gene.