pI: 10.2248 |
Length (AA): 469 |
MW (Da): 53410 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
202 | 396 | 1nt2 (B) | 59 | 265 | 24.00 | 0 | 1 | 0.4 | -0.05 |
204 | 398 | 1nt2 (B) | 73 | 267 | 27.00 | 0.0000051 | 1 | 0.68 | -0.57 |
29 | 404 | 3nmu (A) | 9 | 372 | 32.00 | 0 | 1 | 1.13071 | 0.43 |
67 | 404 | 3pla (A) | 33 | 377 | 36.00 | 0 | 1 | 1.10368 | 0.29 |
114 | 292 | 4uos (A) | 1 | 184 | 14.00 | 0.059 | 0.74 | 0.675663 | -1.08 |
274 | 401 | 3gqu (A) | 243 | 367 | 43.00 | 0.00000000064 | 0.96 | 0.645321 | -0.22 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Sporozoite. | Zanghi G |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127592)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G27120 | putative SAR DNA-binding protein |
Arabidopsis thaliana | AT3G05060 | putative SAR DNA-binding protein |
Babesia bovis | BBOV_II006040 | nucleolar protein NOP5, putative |
Brugia malayi | Bm1_49560 | NOP5/NOP58 |
Candida albicans | CaO19.8790 | similar to S. cerevisiae NOP58 (YOR310C) component of Box C/D snoRNPs |
Candida albicans | CaO19.1199 | similar to S. cerevisiae NOP58 (YOR310C) component of Box C/D snoRNPs |
Caenorhabditis elegans | CELE_W01B11.3 | Protein NOL-5 |
Cryptosporidium hominis | Chro.30248 | snoRNA binding domain |
Cryptosporidium parvum | cgd3_2110 | nucleolar protein NOP5/NOP58-like pre-mRNA splicinig factor prp31 |
Dictyostelium discoideum | DDB_G0268098 | hypothetical protein |
Drosophila melanogaster | Dmel_CG10206 | CG10206 gene product from transcript CG10206-RA |
Echinococcus granulosus | EgrG_000897200 | Nucleolar protein 5 |
Entamoeba histolytica | EHI_183900 | snoRNA binding protein, putative |
Echinococcus multilocularis | EmuJ_000897200 | Nucleolar protein 5 |
Giardia lamblia | GL50803_5359 | Nucleolar protein NOP5 |
Homo sapiens | ENSG00000055044 | NOP58 ribonucleoprotein |
Leishmania braziliensis | LbrM.15.1380 | nucleolar RNA binding protein, putative |
Leishmania donovani | LdBPK_151430.1 | nucleolar RNA binding protein, putative |
Leishmania infantum | LinJ.15.1430 | nucleolar RNA binding protein, putative |
Leishmania major | LmjF.15.1380 | nucleolar RNA binding protein, putative |
Leishmania mexicana | LmxM.15.1380 | nucleolar RNA binding protein, putative |
Loa Loa (eye worm) | LOAG_09461 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12523 | NOP5/NOP58 |
Mus musculus | ENSMUSG00000026020 | NOP58 ribonucleoprotein |
Neospora caninum | NCLIV_020180 | hypothetical protein |
Oryza sativa | 4332841 | Os03g0350300 |
Oryza sativa | 4332840 | Os03g0350100 |
Plasmodium berghei | PBANKA_1207000 | nucleolar protein 5, putative |
Plasmodium falciparum | PF3D7_1008800 | nucleolar protein 5, putative |
Plasmodium knowlesi | PKNH_0808200 | nucleolar protein 5, putative |
Plasmodium vivax | PVX_094640 | nucleolar protein 5, putative |
Plasmodium yoelii | PY05710 | Putative snoRNA binding domain, putative |
Plasmodium yoelii | PY01565 | Putative snoRNA binding domain, putative |
Saccharomyces cerevisiae | YOR310C | RNA-processing protein NOP58 |
Schistosoma japonicum | Sjp_0208100 | Nucleolar protein 5, putative |
Schistosoma mansoni | Smp_148990 | nucleolar protein NOP56 |
Schmidtea mediterranea | mk4.010250.00 | Nucleolar protein 58 |
Schmidtea mediterranea | mk4.032425.00 | Nucleolar protein 58 |
Trypanosoma brucei gambiense | Tbg972.9.2810 | nucleolar RNA binding protein, putative |
Trypanosoma brucei | Tb927.9.5320 | nucleolar RNA binding protein, putative |
Trypanosoma congolense | TcIL3000_9_1780 | nucleolar RNA binding protein, putative |
Trypanosoma cruzi | TcCLB.508277.230 | nucleolar RNA binding protein, putative |
Toxoplasma gondii | TGME49_205510 | nucleolar protein 5, putative |
Theileria parva | TP02_0550 | nuclear protein, putative |
Trichomonas vaginalis | TVAG_459140 | prp31, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_W01B11.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_W01B11.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_W01B11.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_W01B11.3 | Caenorhabditis elegans | sterile | wormbase |
YOR310C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_205510 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.