pI: 5.1381 |
Length (AA): 317 |
MW (Da): 35134 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 307 | 4d4z (A) | 4 | 283 | 29.00 | 0.000016 | 1 | 1.28554 | -0.37 |
7 | 306 | 4d4z (A) | 2 | 282 | 46.00 | 0 | 1 | 1.52017 | -1.11 |
210 | 302 | 4jw3 (C) | 13 | 101 | 34.00 | 0 | 1 | 0.795875 | -1.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128124)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G58180 | ARM repeat superfamily protein |
Babesia bovis | BBOV_IV009880 | PBS lyase HEAT-like repeat domain containing protein |
Brugia malayi | Bm1_56815 | PBS lyase HEAT-like repeat family protein |
Candida albicans | CaO19.2286 | similar to S. cerevisiae YJR070C |
Candida albicans | CaO19.9826 | similar to S. cerevisiae YJR070C |
Caenorhabditis elegans | CELE_C14A4.1 | Protein DOHH-1 |
Cryptosporidium hominis | Chro.40055 | hypothetical protein |
Cryptosporidium parvum | cgd4_410 | protein with 4xEZ_heat domains |
Dictyostelium discoideum | DDB_G0272634 | PBS lyase HEAT-like repeat-containing protein |
Dictyostelium discoideum | DDB_G0274079 | PBS lyase HEAT-like repeat-containing protein |
Drosophila melanogaster | Dmel_CG2245 | CG2245 gene product from transcript CG2245-RA |
Echinococcus granulosus | EgrG_000637700 | deoxyhypusine hydroxylase:monooxygenase |
Echinococcus multilocularis | EmuJ_000637700 | deoxyhypusine hydroxylase:monooxygenase |
Homo sapiens | ENSG00000129932 | deoxyhypusine hydroxylase/monooxygenase |
Leishmania braziliensis | LbrM.26.1840 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_261920.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.26.1920 | hypothetical protein, conserved |
Leishmania major | LmjF.26.1910 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.26.1910 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000078440 | deoxyhypusine hydroxylase/monooxygenase |
Neospora caninum | NCLIV_042540 | PBS lyase HEAT-like repeat domain-containing protein, putative |
Oryza sativa | 4351581 | Os12g0163300 |
Oryza sativa | 4352843 | Os12g0626100 |
Plasmodium berghei | PBANKA_1401100 | deoxyhypusine hydroxylase, putative |
Plasmodium falciparum | PF3D7_1302600 | deoxyhypusine hydroxylase |
Plasmodium knowlesi | PKNH_1402800 | deoxyhypusine hydroxylase, putative |
Plasmodium vivax | PVX_121970 | hypothetical protein, conserved |
Plasmodium yoelii | PY00741 | PBS lyase HEAT-like repeat, putative |
Saccharomyces cerevisiae | YJR070C | Lia1p |
Schistosoma mansoni | Smp_056370 | pbs lyase heat-like protein |
Schmidtea mediterranea | mk4.000111.12 | Deoxyhypusine hydroxylase |
Schmidtea mediterranea | mk4.002413.02 | Deoxyhypusine hydroxylase |
Schmidtea mediterranea | mk4.000111.08 | Deoxyhypusine hydroxylase |
Trypanosoma brucei gambiense | Tbg972.9.1120 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.9.2580 | deoxyhypusine hydroxylase, putative |
Trypanosoma congolense | TcIL3000_9_750 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.507615.70 | deoxyhypusine hydroxylase, putative |
Trypanosoma cruzi | TcCLB.508347.130 | deoxyhypusine hydroxylase, putative |
Theileria parva | TP01_0705 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.1240 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.1240 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.1240 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.1240 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C14A4.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C14A4.1 | Caenorhabditis elegans | slow growth | wormbase |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | deoxyhypusine hydroxylase | Compounds | References |
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Tbru018346; Recombinant protein: full-length; Source: T brucei; hypothetical protein, conserved ; |
1 literature reference was collected for this gene.