pI: 7.0832 |
Length (AA): 145 |
MW (Da): 16775 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
30 | 63 | 2lqt (A) | 16 | 49 | 32.00 | 0 | 0.9 | 0.706383 | -0.8 |
30 | 71 | 1u96 (A) | 26 | 67 | 33.00 | 0.17 | 0.42 | 0.668655 | -0.14 |
30 | 63 | 1ei0 (A) | 3 | 36 | 24.00 | 0 | 0.53 | 0.590383 | -0.81 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_129033)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G66590 | cytochrome c oxidase 19-1 |
Arabidopsis thaliana | AT1G69750 | cytochrome c oxidase 19-2 |
Babesia bovis | BBOV_IV008710 | hypothetical protein |
Babesia bovis | BBOV_IV008720 | hypothetical protein |
Brugia malayi | Bm1_24410 | CHCH domain containing protein |
Candida albicans | CaO19.4967 | Cytochrome oxidase |
Candida albicans | CaO19.12432 | cytochrome oxidase |
Caenorhabditis elegans | CELE_F45H11.5 | Protein F45H11.5 |
Dictyostelium discoideum | DDB_G0288903 | hypothetical protein |
Drosophila melanogaster | Dmel_CG42496 | CG42496 gene product from transcript CG42496-RB |
Homo sapiens | 90639 | COX19 cytochrome c oxidase assembly factor |
Leishmania braziliensis | LbrM.19.1380 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_191180.1 | CHCH domain containing protein, putative |
Leishmania infantum | LinJ.19.1180 | hypothetical protein, conserved |
Leishmania major | LmjF.19.1190 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.19.1190 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05188 | CHCH domain-containing protein |
Mus musculus | 68033 | cytochrome c oxidase assembly protein 19 |
Neospora caninum | NCLIV_008520 | hypothetical protein |
Oryza sativa | 4329136 | Os02g0313500 |
Onchocerca volvulus | OVOC240 |
|
Plasmodium berghei | PBANKA_0600800 | cytochrome c oxidase assembly protein COX19, putative |
Plasmodium falciparum | PF3D7_1201800 | cytochrome c oxidase assembly protein COX19, putative |
Plasmodium knowlesi | PKNH_1301700 | cytochrome c oxidase assembly protein COX19, putative |
Plasmodium vivax | PVX_084115 | cytochrome c oxidase assembly protein COX19, putative |
Plasmodium yoelii | PY04195 | protein Saccharomyces cerevisiae YLL018c-a-related |
Saccharomyces cerevisiae | YLL018C-A | Cox19p |
Schmidtea mediterranea | mk4.014209.01 | |
Trypanosoma brucei gambiense | Tbg972.10.19380 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.10.19340 | hypothetical protein, unlikely |
Trypanosoma brucei | Tb927.10.15790 | CHCH domain containing protein, putative |
Trypanosoma congolense | TcIL3000_10_13600 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511361.50 | CHCH domain containing protein, putative |
Trypanosoma cruzi | TcCLB.508899.100 | CHCH domain containing protein, putative |
Toxoplasma gondii | TGME49_254260 | COX19 cytochrome c oxidase assembly family protein |
Theileria parva | TP01_0902 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.15790 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.15790 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.15790 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.15790 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0600800 | Plasmodium berghei | Essential | plasmo |
TGME49_254260 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.