pI: 9.7976 |
Length (AA): 210 |
MW (Da): 24957 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 135 | 5mi0 (A) | 226 | 405 | 33.00 | 0.0074 | 0.21 | 0.671495 | 1.02 |
22 | 179 | 4v3d (A) | 551 | 715 | 10.00 | 0 | 0.01 | 0.803381 | -0.4 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Gametocyte, 4 hs Ring, 16 hs Trophozoite, 22 hs Schizont, Erthyrocytic stages, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Ookinete, Female gametocyte. | Otto TD Yeoh LM |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Ortholog group members (OG5_129033)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G66590 | cytochrome c oxidase 19-1 |
Arabidopsis thaliana | AT1G69750 | cytochrome c oxidase 19-2 |
Babesia bovis | BBOV_IV008710 | hypothetical protein |
Babesia bovis | BBOV_IV008720 | hypothetical protein |
Brugia malayi | Bm1_24410 | CHCH domain containing protein |
Candida albicans | CaO19.4967 | Cytochrome oxidase |
Candida albicans | CaO19.12432 | cytochrome oxidase |
Caenorhabditis elegans | CELE_F45H11.5 | Protein F45H11.5 |
Dictyostelium discoideum | DDB_G0288903 | hypothetical protein |
Drosophila melanogaster | Dmel_CG42496 | CG42496 gene product from transcript CG42496-RB |
Homo sapiens | 90639 | COX19 cytochrome c oxidase assembly factor |
Leishmania braziliensis | LbrM.19.1380 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_191180.1 | CHCH domain containing protein, putative |
Leishmania infantum | LinJ.19.1180 | hypothetical protein, conserved |
Leishmania major | LmjF.19.1190 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.19.1190 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05188 | CHCH domain-containing protein |
Mus musculus | 68033 | cytochrome c oxidase assembly protein 19 |
Neospora caninum | NCLIV_008520 | hypothetical protein |
Oryza sativa | 4329136 | Os02g0313500 |
Onchocerca volvulus | OVOC240 |
|
Plasmodium berghei | PBANKA_0600800 | cytochrome c oxidase assembly protein COX19, putative |
Plasmodium falciparum | PF3D7_1201800 | cytochrome c oxidase assembly protein COX19, putative |
Plasmodium knowlesi | PKNH_1301700 | cytochrome c oxidase assembly protein COX19, putative |
Plasmodium vivax | PVX_084115 | cytochrome c oxidase assembly protein COX19, putative |
Plasmodium yoelii | PY04195 | protein Saccharomyces cerevisiae YLL018c-a-related |
Saccharomyces cerevisiae | YLL018C-A | Cox19p |
Schmidtea mediterranea | mk4.014209.01 | |
Trypanosoma brucei gambiense | Tbg972.10.19380 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.10.19340 | hypothetical protein, unlikely |
Trypanosoma brucei | Tb927.10.15790 | CHCH domain containing protein, putative |
Trypanosoma congolense | TcIL3000_10_13600 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511361.50 | CHCH domain containing protein, putative |
Trypanosoma cruzi | TcCLB.508899.100 | CHCH domain containing protein, putative |
Toxoplasma gondii | TGME49_254260 | COX19 cytochrome c oxidase assembly family protein |
Theileria parva | TP01_0902 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.15790 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.15790 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.15790 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.15790 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0600800 this record | Plasmodium berghei | Essential | plasmo |
TGME49_254260 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.