pI: 6.5102 |
Length (AA): 679 |
MW (Da): 76556 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
127 | 620 | 5l7j (A) | 7 | 459 | 39.00 | 0 | 1 | 0.967541 | 0.02 |
544 | 619 | 3efa (A) | 63 | 143 | 21.00 | 0.000094 | 0.3 | 0.320929 | -0.39 |
549 | 607 | 2g3a (A) | 60 | 119 | 20.00 | 0.91 | 0.16 | 0.290892 | -0.08 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127324)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G50320 | Elongator complex protein 3 |
Babesia bovis | BBOV_III010020 | histone acetyltransferase, ELP3 family protein |
Brugia malayi | Bm1_32255 | RE35395p |
Candida albicans | CaO19.7387 | Elongator Protein |
Caenorhabditis elegans | CELE_ZK863.3 | Protein ELPC-3 |
Cryptosporidium hominis | Chro.10275 | hypothetical protein |
Cryptosporidium parvum | cgd1_2450 | ELP3 like acetyltransferase involved in transcription |
Dictyostelium discoideum | DDB_G0290103 | GCN5-related N-acetyltransferase |
Drosophila melanogaster | Dmel_CG15433 | Elongator complex protein 3 |
Echinococcus granulosus | EgrG_000482000 | elongator complex protein 3 |
Entamoeba histolytica | EHI_152010 | histone acetyltransferase, putative |
Echinococcus multilocularis | EmuJ_000482000 | elongator complex protein 3 |
Giardia lamblia | GL50803_16639 | Histone acetyltransferase Elp3 |
Homo sapiens | ENSG00000134014 | elongator acetyltransferase complex subunit 3 |
Leishmania braziliensis | LbrM.23.1470 | acetyltransferase-like protein |
Leishmania braziliensis | LbrM.16.0250 | histone acetyltransferase-like protein |
Leishmania donovani | LdBPK_160250.1 | histone acetyltransferase-like protein |
Leishmania donovani | LdBPK_231610.1 | acetyltransferase-like protein |
Leishmania infantum | LinJ.16.0250 | histone acetyltransferase-like protein |
Leishmania infantum | LinJ.23.1610 | acetyltransferase-like protein |
Leishmania major | LmjF.23.1350 | acetyltransferase-like protein |
Leishmania major | LmjF.16.0240 | histone acetyltransferase-like protein |
Leishmania mexicana | LmxM.23.1350 | acetyltransferase-like protein |
Leishmania mexicana | LmxM.16.0240 | histone acethyltransferase-like protein |
Loa Loa (eye worm) | LOAG_09530 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11221 | hypothetical protein |
Mus musculus | ENSMUSG00000022031 | elongator acetyltransferase complex subunit 3 |
Neospora caninum | NCLIV_043970 | elongator complex protein 3, putative |
Oryza sativa | 4336205 | Os04g0484900 |
Plasmodium berghei | PBANKA_1442500 | elongator complex protein 3, putative |
Plasmodium falciparum | PF3D7_1227800 | elongator complex protein 3, putative |
Plasmodium knowlesi | PKNH_1447200 | elongator complex protein 3, putative |
Plasmodium yoelii | PY03999 | hypothetical protein |
Saccharomyces cerevisiae | YPL086C | Elongator subunit ELP3 |
Schistosoma japonicum | Sjp_0067110 | Probable elongator complex protein 3, putative |
Schistosoma japonicum | Sjp_0096190 | Elongator complex protein 3, putative |
Schistosoma japonicum | Sjp_0067100 | ko:K07739 histone acetyltransferase, ELP3 family, putative |
Schistosoma mansoni | Smp_085500 | histone acetyltransferase-related |
Schmidtea mediterranea | mk4.003323.03 | Probable elongator complex protein 3 |
Trypanosoma brucei gambiense | Tbg972.8.5770 | histone acethyltransferase, putative |
Trypanosoma brucei gambiense | Tbg972.8.3070 | acetyltransferase, putative |
Trypanosoma brucei | Tb11.v5.0520 | acetyltransferase, putative |
Trypanosoma brucei | Tb927.8.3310 | Elongator-like Protein 3b |
Trypanosoma brucei | Tb927.8.5770 | Elongator-like Protein 3a |
Trypanosoma congolense | TcIL3000_8_5560 | histone acetyltransferase, putative |
Trypanosoma congolense | TcIL3000_8_3370 | acetyltransferase, putative |
Trypanosoma cruzi | TcCLB.506743.120 | Elongator-like Protein 3a, putative |
Trypanosoma cruzi | TcCLB.503851.10 | Elongator-like Protein 3a, putative |
Trypanosoma cruzi | TcCLB.509769.110 | Elongator-like Protein 3b, putative |
Toxoplasma gondii | TGME49_305480 | elongator complex protein ELP3 |
Theileria parva | TP02_0146 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_028740 | elongator complex protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.5770 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5770 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5770 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.5770 this record | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.8.3310 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3310 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3310 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.3310 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1442500 | Plasmodium berghei | Essential | plasmo |
TGME49_305480 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.